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Open AccessArticle

Rapid Chairside Microbial Detection Predicts Endodontic Treatment Outcome

Department of Endodontics, Faculty of Dentistry, Oral and Craniofacial Sciences, Floor 22 Tower Wing, Guy’s Dental Hospital, London SE1 9RT, UK
Department of Conservative Dentistry, College of Dentistry, University of Baghdad, Baghdad 10001, Iraq
Specialist practice, London W1G 8SB, UK
Department of Therapeutic Dentistry, I. M. Sechenov First Moscow State Medical University, 119146 Moscow, Russia
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2086;
Received: 16 June 2020 / Accepted: 30 June 2020 / Published: 3 July 2020
(This article belongs to the Special Issue Clinical Research of Endodontic Dentistry)
Background. The aim of this longitudinal, one-year cohort study was to explore the hypothesis that fluorescence sampling of the root canal space prior to obturation could predict the outcome of root canal treatment (RCT). Methods. Sixty-five teeth underwent primary RCT and were followed up clinically and radiographically. The outcome was determined radiographically with periapical radiographs (PR) and cone beam computed tomography (CBCT) scans. Results. Success at 12 months was predictable based on the fluorescence score. When the fluorescence score (defined as the percentage of signal over total signal including background) was lower than 67, there was a 4.5 times (Odds ratio (OR) = 0.028; 95% confidence interval (CI): 0.003, 0.291, p = 0.001) greater chance of success (90% overall). When the readings were above this threshold, the success rate was 20%. Conclusion. A chairside sampling method is able to predict the outcome of RCT, through the use of paper point sampling and fluorescence staining. This has reduced the prevalence of persistent infections by guiding the optimum time for obturation. trial NCT03660163. View Full-Text
Keywords: endodontics; clinical outcomes; bacteria; biofilm(s); clinical studies/trials; computed tomography endodontics; clinical outcomes; bacteria; biofilm(s); clinical studies/trials; computed tomography
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Knight, A.; Blewitt, I.; Al-Nuaimi, N.; Watson, T.; Herzog, D.; Festy, F.; Patel, S.; Foschi, F.; Koller, G.; Mannocci, F. Rapid Chairside Microbial Detection Predicts Endodontic Treatment Outcome. J. Clin. Med. 2020, 9, 2086.

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