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Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm

1
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan
2
Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto 861-4193, Japan
3
Department of Cardiology, Fujita Health University, Toyoake 470-1101, Japan
4
Cardiovascular Center, Yokohama City University Medical Center, Yokohama 236-0004, Japan
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Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara 252-0375, Japan
6
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita 565-8565, Japan
7
Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni 410-2295, Japan
8
Department of Cardiology, National Hospital Organization Kumamoto Medical Center, Kumamoto 860-0008, Japan
9
Department of Cardiology, Hiroshima City Hospital, Hiroshima 730-8518, Japan
10
Division of Cardiology, Osaka General Medical Center, Osaka 558-8558, Japan
11
Department of Cardiovascular Medicine, Nippon Medical School, Tokyo 113-8603, Japan
12
First Department of Internal Medicine, Nara Medical University, Kashihara 634-8521, Japan
13
Department of Cardiovascular Medicine, The Sakakibara Heart Institute of Okayama, Okayama 700-0804, Japan
14
Department of Cardiology, Ogaki Municipal Hospital, Ogaki 503-8502, Japan
15
Department of Cardiovascular Medicine, Dokkyo Medical University, Tochigi 321-0293, Japan
16
Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka 530-0001, Japan
17
Institute for Clinical Research, Kansai Rosai Hospital, Osaka 660-8511, Japan
18
Department of Cardiology, Okinawa Chubu Hospital, Uruma 904-2293, Japan
19
Division of Cardiology, Mitsui Memorial Hospital, Tokyo 101-8043, Japan
20
Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki 880-0834, Japan
21
Department of Cardiovascular Medicine, Suwa Red Cross Hospital, Suwa 392-8510, Japan
22
Division of Cardiovascular Medicine, Saitama Medical Center Jichi Medical University, Saitama 330-8503, Japan
23
Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University, Sapporo 060-8543, Japan
24
Department of Cardiology, Teikyo University, Tokyo 173-8606, Japan
25
Department of Cardiology, Kawasaki Medical School, Kurashiki 701-0192, Japan
26
Department of Cardiology, Sakakibara Heart Institute, Tokyo 183-0003, Japan
27
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0133, Japan
28
Department of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi 371-0004, Japan
29
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita 565-8565, Japan
30
Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, Nishinomiya 663-8501, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1686; https://doi.org/10.3390/jcm9061686
Received: 30 April 2020 / Revised: 25 May 2020 / Accepted: 27 May 2020 / Published: 2 June 2020
(This article belongs to the Special Issue Clinical Research of Percutaneous Coronary Intervention)
While prognoses in relation to myocardial infarction (MI) type have been elucidated in past reports, the results were not consistent, perhaps due to occurrence of Type 2 MI with CVS and its mortality. The Japanese registry of acute Myocardial Infarction diagnosed by Universal Definition (J-MINUET) is a prospective multicenter registry in Japan. In contrast to thromboembolic event-related Type 1 myocardial infarction (MI), clinical features of Type 2 MI, including coronary vasospasm (CVS), are varied due to the heterogeneous nature of its development. To elucidate the MI type-related all-cause mortality, 2989 consecutive patients with AMI were stratified as Type 1 MI, Type 2 MI with CVS, and Type 2 MI with non-CVS. Most patients (n = 2834; 94.8%) were classified as Type 1 MI and 155 patients (5.2%) were classified as Type 2 MI. Of the Type 2 MI patients, 87 (56% of Type 2 MI) were diagnosed as MI with CVS. Although the 3-year mortality was comparable between Type 1 and Type 2 MI patients, significant differences were observed between Type 2 MI with CVS and with non-CVS (3.4% and 22.1%, p < 0.001). Among Japanese patients with AMI, mortality rates between Type 1 MI and Type 2 MI are comparable, but further stratification of Type 2 MI (with or without CVS) may be useful in predicting the prognosis of patients with Type 2 MI. View Full-Text
Keywords: acute myocardial infarction; clinical outcomes; coronary vasospasm; universal definition of myocardial infarction acute myocardial infarction; clinical outcomes; coronary vasospasm; universal definition of myocardial infarction
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MDPI and ACS Style

Sato, R.; Sakamoto, K.; Kaikita, K.; Tsujita, K.; Nakao, K.; Ozaki, Y.; Kimura, K.; Ako, J.; Noguchi, T.; Yasuda, S.; Suwa, S.; Fujimoto, K.; Nakama, Y.; Morita, T.; Shimizu, W.; Saito, Y.; Hirohata, A.; Morita, Y.; Inoue, T.; Okamura, A.; Mano, T.; Hirata, K.; Tanabe, K.; Shibata, Y.; Owa, M.; Funayama, H.; Kokubu, N.; Kozuma, K.; Uemura, S.; Toubaru, T.; Saku, K.; Ohshima, S.; Nishimura, K.; Miyamoto, Y.; Ogawa, H.; Ishihara, M., on behalf of J-MINUET Investigators. Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm. J. Clin. Med. 2020, 9, 1686. https://doi.org/10.3390/jcm9061686

AMA Style

Sato R, Sakamoto K, Kaikita K, Tsujita K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M on behalf of J-MINUET Investigators. Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm. Journal of Clinical Medicine. 2020; 9(6):1686. https://doi.org/10.3390/jcm9061686

Chicago/Turabian Style

Sato, Ryota, Kenji Sakamoto, Koichi Kaikita, Kenichi Tsujita, Koichi Nakao, Yukio Ozaki, Kazuo Kimura, Junya Ako, Teruo Noguchi, Satoshi Yasuda, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Toshiaki Mano, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Hiroshi Funayama, Nobuaki Kokubu, Ken Kozuma, Shirou Uemura, Tetsuya Toubaru, Keijirou Saku, Shigeru Ohshima, Kunihiro Nishimura, Yoshihiro Miyamoto, Hisao Ogawa, and Masaharu Ishihara on behalf of J-MINUET Investigators. 2020. "Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm" Journal of Clinical Medicine 9, no. 6: 1686. https://doi.org/10.3390/jcm9061686

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