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Article

Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis

by 1, 2, 2, 2,3, 1,2 and 1,2,*
1
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
2
Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
3
Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1661; https://doi.org/10.3390/jcm9061661
Received: 28 April 2020 / Revised: 18 May 2020 / Accepted: 26 May 2020 / Published: 1 June 2020
(This article belongs to the Section Hematology)
Recent studies have suggested that TNF-related apoptosis-inducing ligand (TRAIL) is associated with mortality in sepsis, possibly through necroptosis. The objective of this study was to analyze the association between the plasma level of TRAIL and sepsis severity and outcomes. Furthermore, the plasma level of TRAIL was compared to that of receptor-interacting protein kinase-3 (RIPK3), a key executor of necroptosis, to identify any correlation between TRAIL and necroptosis. Plasma levels of TRAIL and RIPK3 from consecutively enrolled critically ill patients were measured by ELISA. Of 190 study patients, 59 (31.1%) and 84 (44.2%) patients were diagnosed with sepsis and septic shock, respectively. There was a trend of decreased plasma level of TRAIL across the control, sepsis, and septic shock groups. For 143 patients with sepsis, patients with low plasma TRAIL were more likely to have septic shock and higher SAPS3 and SOFA scores. However, no difference in 28-day and 90-day mortalities was observed between the two groups. The plasma level of TRAIL was inversely associated with RIPK3 in patients with sepsis. Plasma levels of TRAIL increased over time on days three and seven, and were inversely associated with sepsis severity and RIPK3 level, but not with mortality. View Full-Text
Keywords: biomarker; necroptosis; RIPK3 protein; sepsis; TNF-related apoptosis-inducing ligand biomarker; necroptosis; RIPK3 protein; sepsis; TNF-related apoptosis-inducing ligand
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MDPI and ACS Style

Yoo, H.; Lee, J.Y.; Park, J.; Yang, J.H.; Suh, G.Y.; Jeon, K. Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis. J. Clin. Med. 2020, 9, 1661. https://doi.org/10.3390/jcm9061661

AMA Style

Yoo H, Lee JY, Park J, Yang JH, Suh GY, Jeon K. Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis. Journal of Clinical Medicine. 2020; 9(6):1661. https://doi.org/10.3390/jcm9061661

Chicago/Turabian Style

Yoo, Hongseok, Jin Y. Lee, Junseon Park, Jeong H. Yang, Gee Y. Suh, and Kyeongman Jeon. 2020. "Association of Plasma Level of TNF-Related Apoptosis-Inducing Ligand with Severity and Outcome of Sepsis" Journal of Clinical Medicine 9, no. 6: 1661. https://doi.org/10.3390/jcm9061661

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