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Article

Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study

1
Department of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan
2
Department of Health and Welfare Services, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama 351-0197, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1635; https://doi.org/10.3390/jcm9061635
Received: 1 May 2020 / Revised: 22 May 2020 / Accepted: 25 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Novel Insights into Non Alcoholic Fatty Liver Disease)
It is unclear whether the link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) is mediated by common risk factors. We aimed to elucidate the association between NAFLD and CKD using propensity score (PS)-matched analysis. We assessed 3725 Japanese individuals, excluding those with hepatitis B or C infection and men and women who consumed >30 and >20 g/day of alcohol, respectively. Of these, we enrolled 1097 Japanese subjects with NAFLD diagnosed by ultrasonography and 1097 PS-matched subjects without NAFLD. The prevalence of CKD was higher in subjects with NAFLD than in those without NAFLD before PS matching, but there was no significant difference between these groups in terms of CKD prevalence after PS matching. There was no difference in the prevalence of CKD between those with and without NAFLD in the subgroup analyses. Logistic regression analysis demonstrated that obesity, hypertension, and hyperuricemia were independent predictors of CKD, but NAFLD was not independently associated with CKD. In subjects with NAFLD, obesity, hypertension, and hyperuricemia were independent predictors of CKD. Thus, the link between NAFLD and CKD may be mediated by common risk factors. We recommend screening for CKD when patients with NAFLD have the aforementioned comorbidities. View Full-Text
Keywords: non-alcoholic fatty liver disease; chronic kidney disease; hepatic steatosis; obesity; hypertension; hyperuricemia; comorbidity non-alcoholic fatty liver disease; chronic kidney disease; hepatic steatosis; obesity; hypertension; hyperuricemia; comorbidity
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MDPI and ACS Style

Akahane, T.; Akahane, M.; Namisaki, T.; Kaji, K.; Moriya, K.; Kawaratani, H.; Takaya, H.; Sawada, Y.; Shimozato, N.; Fujinaga, Y.; Furukawa, M.; Kitagawa, K.; Ozutsumi, T.; Tsuji, Y.; Kaya, D.; Mitoro, A.; Yoshiji, H. Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study. J. Clin. Med. 2020, 9, 1635. https://doi.org/10.3390/jcm9061635

AMA Style

Akahane T, Akahane M, Namisaki T, Kaji K, Moriya K, Kawaratani H, Takaya H, Sawada Y, Shimozato N, Fujinaga Y, Furukawa M, Kitagawa K, Ozutsumi T, Tsuji Y, Kaya D, Mitoro A, Yoshiji H. Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study. Journal of Clinical Medicine. 2020; 9(6):1635. https://doi.org/10.3390/jcm9061635

Chicago/Turabian Style

Akahane, Takemi, Manabu Akahane, Tadashi Namisaki, Kosuke Kaji, Kei Moriya, Hideto Kawaratani, Hiroaki Takaya, Yasuhiko Sawada, Naotaka Shimozato, Yukihisa Fujinaga, Masanori Furukawa, Koh Kitagawa, Takahiro Ozutsumi, Yuki Tsuji, Daisuke Kaya, Akira Mitoro, and Hitoshi Yoshiji. 2020. "Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study" Journal of Clinical Medicine 9, no. 6: 1635. https://doi.org/10.3390/jcm9061635

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