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Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits

Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, UK
Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
Department of Dermatology and Allergology, University of Szeged, 6720 Szeged, Hungary
Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China
Nature Medicine, New York, NY 10004-1562, USA
Department of Pharmacology and Pharmacotherapy, University of Szeged, 6720 Szeged, Hungary
NIHR Dissemination Centre, University of Southampton, Southampton SO16 7NS, UK
Weill Cornell Medical College, New York, NY 10065, USA
National Institute for Health Research, Southampton SO16 7NS, UK
Biostatistics and Health Informatics, King’s College London, London WC2R 2LS, UK
Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Dermatology Centre, NIHR Manchester Biomedical Research Centre, University of Manchester, Manchester M13 9WU, UK
Medical University of Gdańsk, 80-210 Gdańsk, Poland
UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK
Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Achucarro Centre for Neuroscience, IKERBASQUE, Basque Foundation for Science, E-48940 Bilbao, Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(5), 1532;
Received: 1 April 2020 / Revised: 14 May 2020 / Accepted: 15 May 2020 / Published: 19 May 2020
(This article belongs to the Section Epidemiology & Public Health)
Introduction: Translational science has gained prominence in medicine, but there is still much work to be done before scientific results are used optimally and incorporated into everyday health practice. As the main focus is still on generating new scientific data with financial resources primarily available for that purpose, other activities that are necessary in the transition from research to community benefit are considered less needy. The European Statistical Office of the European Commission has recently reported that 1.7 million people under 75 years of age died in Europe in 2016, with around 1.2 million of those deaths being avoidable through effective primary prevention and public health intervention. Therefore, Academia Europaea, one of the five Pan-European networks that form SAPEA (Science Advice for Policy by European Academies), a key element of the European Commission’s Scientific Advice Mechanism (SAM), has launched a project to develop a model to facilitate and accelerate the utilisation of scientific knowledge for public and community benefit. Methods: During the process, leaders in the field, including prominent basic and clinical researchers, editors-in-chief of high-impact journals publishing translational research articles, translational medicine (TM) centre leaders, media representatives, academics and university leaders, developed the TM cycle, a new model that we believe could significantly advance the development of TM. Results: This model focuses equally on the acquisition of new scientific results healthcare, understandable and digestible summation of results, and their communication to all participants. We have also renewed the definition in TM, identified challenges and recommended solutions. Conclusion: The authors, including senior officers of Academia Europaea, produced this document to serve as a basis for revising thinking on TM with the end result of enabling more efficient and cost-effective healthcare. View Full-Text
Keywords: translational medicine; translation; healthcare; science; knowledge; communication; interdisciplinary translational medicine; translation; healthcare; science; knowledge; communication; interdisciplinary
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Hegyi, P.; Petersen, O.H.; Holgate, S.; Erőss, B.; Garami, A.; Szakács, Z.; Dobszai, D.; Balaskó, M.; Kemény, L.; Peng, S.; Monteiro, J.; Varró, A.; Lamont, T.; Laurence, J.; Gray, Z.; Pickles, A.; FitzGerald, G.A.; Griffiths, C.E.; Jassem, J.; Rusakov, D.A.; Verkhratsky, A.; Szentesi, A. Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits. J. Clin. Med. 2020, 9, 1532.

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