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Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials

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Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland
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Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60-535 Poznan, Poland
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Department of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, Poland
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School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK
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Division of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, 60-535 Poznan, Poland
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Division of Reproduction, Department of Obstetrics, Gynecology, and Gynecologic Oncology, Poznań University of Medical Sciences, 33 Polna St, 60-535 Poznań, Poland
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Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, 07023-070 São Paulo, Brazil
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Department of Toxicology, Poznan University of Medical Sciences, 61-631 Poznan, Poland
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Physiology Graduate Program, North Carolina State University, Raleigh, NC 27695, USA
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Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
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Division of Anatomy and Histology, University of Zielona Góra, 65-046 Zielona Góra, Poland
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Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 602 00 Brno, Czech Republic
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Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
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Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(4), 1102; https://doi.org/10.3390/jcm9041102
Received: 24 February 2020 / Revised: 30 March 2020 / Accepted: 10 April 2020 / Published: 12 April 2020
(This article belongs to the Section Clinical Laboratory Medicine)
Stem cell therapies offer a great promise for regenerative and reconstructive medicine, due to their self-renewal and differentiation capacity. Although embryonic stem cells are pluripotent, their utilization involves embryo destruction and is ethically controversial. Therefore, adult tissues that have emerged as an alternative source of stem cells and perinatal tissues, such as the umbilical cord, appear to be particularly attractive. Wharton’s jelly, a gelatinous connective tissue contained in the umbilical cord, is abundant in mesenchymal stem cells (MSCs) that express CD105, CD73, CD90, Oct-4, Sox-2, and Nanog among others, and have the ability to differentiate into osteogenic, adipogenic, chondrogenic, and other lineages. Moreover, Wharton’s jelly-derived MSCs (WJ-MSCs) do not express MHC-II and exhibit immunomodulatory properties, which makes them a good alternative for allogeneic and xenogeneic transplantations in cellular therapies. Therefore, umbilical cord, especially Wharton’s jelly, is a promising source of mesenchymal stem cells. View Full-Text
Keywords: stem cells; Wharton’s jelly; umbilical cord stem cells; Wharton’s jelly; umbilical cord
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MDPI and ACS Style

Stefańska, K.; Ożegowska, K.; Hutchings, G.; Popis, M.; Moncrieff, L.; Dompe, C.; Janowicz, K.; Pieńkowski, W.; Gutaj, P.; Shibli, J.A.; Prado, W.M.; Piotrowska-Kempisty, H.; Mozdziak, P.; Bruska, M.; Zabel, M.; Kempisty, B.; Nowicki, M. Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials. J. Clin. Med. 2020, 9, 1102. https://doi.org/10.3390/jcm9041102

AMA Style

Stefańska K, Ożegowska K, Hutchings G, Popis M, Moncrieff L, Dompe C, Janowicz K, Pieńkowski W, Gutaj P, Shibli JA, Prado WM, Piotrowska-Kempisty H, Mozdziak P, Bruska M, Zabel M, Kempisty B, Nowicki M. Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials. Journal of Clinical Medicine. 2020; 9(4):1102. https://doi.org/10.3390/jcm9041102

Chicago/Turabian Style

Stefańska, Katarzyna, Katarzyna Ożegowska, Greg Hutchings, Małgorzata Popis, Lisa Moncrieff, Claudia Dompe, Krzysztof Janowicz, Wojciech Pieńkowski, Paweł Gutaj, Jamil A. Shibli, Walterson Mathias Prado, Hanna Piotrowska-Kempisty, Paul Mozdziak, Małgorzata Bruska, Maciej Zabel, Bartosz Kempisty, and Michał Nowicki. 2020. "Human Wharton’s Jelly—Cellular Specificity, Stemness Potency, Animal Models, and Current Application in Human Clinical Trials" Journal of Clinical Medicine 9, no. 4: 1102. https://doi.org/10.3390/jcm9041102

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