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Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic Review

1
Psychological Sciences Research Institute, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium
2
Institute of Neuroscience, Université Catholique de Louvain, 1348 Louvain-la-Neuve, Belgium
3
Department of Otolaryngology, Head and Neck Surgery, University Hospitals Leuven, 3000 Leuven, Belgium
4
KU Leuven, Research Group ExpORL, Department of Neurosciences, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(3), 812; https://doi.org/10.3390/jcm9030812
Received: 13 January 2020 / Revised: 5 March 2020 / Accepted: 13 March 2020 / Published: 17 March 2020
(This article belongs to the Special Issue Therapies for Hearing Loss)
Neuroplasticity following bilateral deafness and auditory restoration has been repeatedly investigated. In clinical practice, however, a significant number of patients present a severe-to-profound unilateral hearing loss (UHL). To date, less is known about the neuroplasticity following monaural hearing deprivation and auditory input restoration. This article provides an overview of the current research insights on the impact of UHL on the brain and the effect of auditory input restoration with a cochlear implant (CI). An exhaustive systematic review of the literature was performed selecting 38 studies that apply different neural analyses techniques. The main results show that the hearing ear becomes functionally dominant after monaural deprivation, reshaping the lateralization of the neural network for auditory processing, a process that can be considered to influence auditory restoration. Furthermore, animal models predict that the onset time of UHL impacts auditory restoration. Hence, the results seem to advocate for early restoration of UHL, although further research is required to disambiguate the effects of duration and onset of UHL on auditory restoration and on structural neuroplasticity following UHL deprivation and restoration. Ongoing developments on CI devices compatible with Magnetic Resonance Imaging (MRI) examinations will provide a unique opportunity to investigate structural and functional neuroplasticity following CI restoration more directly. View Full-Text
Keywords: brain plasticity; cochlear implant (CI); congenital deafness; cross-modal reorganization; intra-modal reorganization; postlingual deafness; neuroimaging; single-sided deafness; unilateral hearing loss brain plasticity; cochlear implant (CI); congenital deafness; cross-modal reorganization; intra-modal reorganization; postlingual deafness; neuroimaging; single-sided deafness; unilateral hearing loss
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MDPI and ACS Style

Vanderauwera, J.; Hellemans, E.; Verhaert, N. Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic Review. J. Clin. Med. 2020, 9, 812. https://doi.org/10.3390/jcm9030812

AMA Style

Vanderauwera J, Hellemans E, Verhaert N. Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic Review. Journal of Clinical Medicine. 2020; 9(3):812. https://doi.org/10.3390/jcm9030812

Chicago/Turabian Style

Vanderauwera, Jolijn, Elisabeth Hellemans, and Nicolas Verhaert. 2020. "Research Insights on Neural Effects of Auditory Deprivation and Restoration in Unilateral Hearing Loss: A Systematic Review" Journal of Clinical Medicine 9, no. 3: 812. https://doi.org/10.3390/jcm9030812

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