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Open AccessArticle

Subacute Thyroiditis is Associated with HLA-B*18:01, -DRB1*01 and -C*04:01—The Significance of the New Molecular Background

1
Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital Research Institute, 281/289 Rzgowska St., 93-338 Lodz, Poland
2
Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 251 Pomorska St, 92-213 Lodz, Poland
3
Institute of Information Technology, Lodz University of Technology, 215 Wolczanska St., 90-924 Lodz, Poland
4
Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, 281/289 Rzgowska St., 93-338 Lodz, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 534; https://doi.org/10.3390/jcm9020534
Received: 5 February 2020 / Accepted: 13 February 2020 / Published: 16 February 2020
(This article belongs to the Section Molecular Diagnostics)
Subacute thyroiditis (SAT) is a thyroid inflammatory disease whose pathogenesis is still not completely defined. Previous viral infection is considered to be a triggering factor in genetically predisposed individuals. In about 70% of patients, susceptibility to SAT is associated with the HLA-B*35 allele. The correlation between SAT and other human leukocyte antigens (HLA) has not yet been unequivocally demonstrated and the genetic background is still unknown in about 30% of patients. The purpose of our study was to perform HLA genotyping using a next-generation sequencing method, to find out whether alleles other than HLA-B*35 are correlated with SAT morbidity. HLA-A, -B, -C, -DQB1, -DRB1 were genotyped using a next-generation sequencing method in 1083 subjects, including 60 SAT patients and 1023 healthy controls. Among 60 patients diagnosed with SAT, 81.7% of subjects were identified as having allele HLA-B*35, 23.3% had HLA-B*18:01, 28.3% had HLA-DRB1*01 and 75.5% had HLA-C*04:01. These alleles occurred in the control group at frequencies of 10.2%, 7.2%, 12.9% and 12.5%, respectively. The differences were statistically significant, with p < 0.05. In addition to its previously described relationship with HLA-B*35, genetic susceptibility to SAT was associated with the presence of HLA-B*18:01, DRB1*01 and C*04:01. The alleles HLA-B*18:01 and DRB1*01 were independent SAT risk factors. The assessment of these four alleles allows the confirmation of genetic predisposition in almost all patients with SAT. View Full-Text
Keywords: HLA-B*35; HLA-B*18:01; HLA-DRB1*01; HLA-C*04:01; subacute thyroiditis HLA-B*35; HLA-B*18:01; HLA-DRB1*01; HLA-C*04:01; subacute thyroiditis
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Stasiak, M.; Tymoniuk, B.; Michalak, R.; Stasiak, B.; Kowalski, M.L.; Lewiński, A. Subacute Thyroiditis is Associated with HLA-B*18:01, -DRB1*01 and -C*04:01—The Significance of the New Molecular Background. J. Clin. Med. 2020, 9, 534.

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