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Review

Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review

1
Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy
2
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Division of Complex Operating Unit of Dentistry, “Aldo Moro” University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
3
Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy
4
Department of Surgical Sciences, Dental School, University of Turin, 10126 Torino, Italy
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(2), 457; https://doi.org/10.3390/jcm9020457
Received: 11 January 2020 / Revised: 4 February 2020 / Accepted: 5 February 2020 / Published: 7 February 2020
(This article belongs to the Section Stomatology)
Actinomyces are anaerobic, rod-shaped, Gram-positive bacteria. They are associated with persistent extraradicular endodontic infections, with possible involvement of the soft tissues of the maxillofacial district. Many studies reported conflicting data on the presence of bacteria of the genus Actinomyces in endodontic infections. The aim of this systematic review of the literature was to determine the real prevalence of such bacteria in primary and/or secondary endodontic infections and in cases of persistence with extraradicular involvement. This systematic review was performed according to the PRISMA protocol. A search was carried out through the Scopus and PubMed databases of potentially eligible articles through the use of appropriate keywords. The literature research resulted in preliminary 2240 records which, after the elimination of overlaps and the application of inclusion and exclusion criteria, led to the inclusion of 46 articles focusing on three outcomes (primary outcome: number of teeth with the presence of a persistent extraradicular infection in which the presence of Actinomyces was ascertained; secondary outcome: number of teeth with endodontic infection in which the presence of Actinomyces was assessed; tertiary outcome: difference in the prevalence of bacteria of the genus Actinomyces between primary endodontic infections and secondary endodontic infections). Results of the meta-analysis show how bacteria of the genus Actinomyces are present in primary and secondary intraradicular infections and in those with persistence with a prevalence (ratio between teeth with actinomyces and teeth with infection) ranging from 0.091 up to 0.130 depending on the subgroups analyzed. View Full-Text
Keywords: endodontic; infections; root canal therapy; actinomyces endodontic; infections; root canal therapy; actinomyces
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MDPI and ACS Style

Dioguardi, M.; Crincoli, V.; Laino, L.; Alovisi, M.; Sovereto, D.; Lo Muzio, L.; Troiano, G. Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review. J. Clin. Med. 2020, 9, 457. https://doi.org/10.3390/jcm9020457

AMA Style

Dioguardi M, Crincoli V, Laino L, Alovisi M, Sovereto D, Lo Muzio L, Troiano G. Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review. Journal of Clinical Medicine. 2020; 9(2):457. https://doi.org/10.3390/jcm9020457

Chicago/Turabian Style

Dioguardi, Mario, Vito Crincoli, Luigi Laino, Mario Alovisi, Diego Sovereto, Lorenzo Lo Muzio, and Giuseppe Troiano. 2020. "Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review" Journal of Clinical Medicine 9, no. 2: 457. https://doi.org/10.3390/jcm9020457

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