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Article

Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies

1
Department of Neurology and Stroke Center, APHP Bichat Hospital, F-75018 Paris, France
2
LVTS, Inserm U1148, Université de Paris, F-75018 Paris, France
3
Department of Biostatistics Université de Lille, CHU Lille, ULR 2694-METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4028; https://doi.org/10.3390/jcm9124028
Received: 24 November 2020 / Revised: 4 December 2020 / Accepted: 9 December 2020 / Published: 13 December 2020
(This article belongs to the Section Clinical Neurology)
Establishing a prognosis at hospital admission after stroke is a major challenge. Inflammatory processes, hemostasis, vascular injury, and tissue remodeling are all involved in the early response to stroke. This study analyzes whether 22 selected biomarkers, sampled at admission, predict clinical outcomes in 153 stroke patients treated by thrombolysis and mechanical endovascular treatment (MET). Biomarkers were related to hemostasis (u-plasminogen activator/urokinase (uPA/urokinase), serpin E1/PAI-1, serpin C1/antithrombin-III, kallikrein 6/neurosin, alpha 2-macroglobulin), inflammation[myloperoxidase (MPO), chemokine ligand 2/monocyte chemoattractant protein-1 chemokine (CCL2/MCP-1), adiponectin, resistin, cell-free DNA (cDNA), CD40 Ligand (CD40L)], endothelium activation (Vascular cell adhesion protein 1 (VCAM-1) intercellular adhesion molecule 1 (ICAM-1), platelet endothelial cell adhesion molecule 1 (CD31/PECAM-1)], and tissue remodeling (total cathepsin S, osteopontin, cystatin C, neuropilin-1, matrix metallopeptidase 2 (MMP-2), matrix metallopeptidase 3 (MMP-3), matrix metallopeptidase 9 (MMP-9), matrix metallopeptidase 13 (MMP-13)]. Correlations between their levels and excellent neurological improvement (ENI) at 24 h and good outcomes (mRS 0–2) at three months were tested. Osteopontin and favorable outcomes reached the significance level (p = 0.008); the adjusted OR per SD increase in log-transformed osteopontin was 0.34 (95%CI, 0.18–0.62). The relationship between total cathepsin S and MPO with ENI, was borderline of significance (p = 0.064); the adjusted OR per SD increase in log-transformed of total cathepsin S and MPO was 0.54 (95%CI, 0.35–0.81) and 0.51 (95%CI, 0.32–0.80), respectively. In conclusion, osteopontin levels predicted three-month favorable outcomes, supporting the use of this biomarker as a complement of clinical and radiological parameters for predicting stroke prognosis. View Full-Text
Keywords: acute stroke; biomarkers; assessment; outcomes; thrombolytic therapy; thrombectomy acute stroke; biomarkers; assessment; outcomes; thrombolytic therapy; thrombectomy
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MDPI and ACS Style

Meseguer, E.; Diallo, D.; Labreuche, J.; Charles, H.; Delbosc, S.; Mangin, G.; Monteiro Tavares, L.; Caligiuri, G.; Nicoletti, A.; Amarenco, P. Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies. J. Clin. Med. 2020, 9, 4028. https://doi.org/10.3390/jcm9124028

AMA Style

Meseguer E, Diallo D, Labreuche J, Charles H, Delbosc S, Mangin G, Monteiro Tavares L, Caligiuri G, Nicoletti A, Amarenco P. Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies. Journal of Clinical Medicine. 2020; 9(12):4028. https://doi.org/10.3390/jcm9124028

Chicago/Turabian Style

Meseguer, Elena; Diallo, Devy; Labreuche, Julien; Charles, Hugo; Delbosc, Sandrine; Mangin, Gabrielle; Monteiro Tavares, Linsay; Caligiuri, Giuseppina; Nicoletti, Antonino; Amarenco, Pierre. 2020. "Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies" J. Clin. Med. 9, no. 12: 4028. https://doi.org/10.3390/jcm9124028

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