Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study

Background: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. Results: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, p = 0.004; at 2 h, p = 0.018). Conclusions: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature. View Full-Text

Keywords: anterior segment optical coherence tomography angiography; anti-glaucoma eyedrop; aqueous humor outflow pathway; intraocular pressure reduction

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Akagi, T.; Okamoto, Y.; Kameda, T.; Suda, K.; Nakanishi, H.; Miyake, M.; Ikeda, H.O.; Yamada, T.; Kadomoto, S.; Uji, A.; Tsujikawa, A. Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study. J. Clin. Med. 2020, 9, 4016. https://doi.org/10.3390/jcm9124016

AMA Style

Akagi T, Okamoto Y, Kameda T, Suda K, Nakanishi H, Miyake M, Ikeda HO, Yamada T, Kadomoto S, Uji A, Tsujikawa A. Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study. Journal of Clinical Medicine. 2020; 9(12):4016. https://doi.org/10.3390/jcm9124016

Chicago/Turabian Style

Akagi, Tadamichi, Yoko Okamoto, Takanori Kameda, Kenji Suda, Hideo Nakanishi, Masahiro Miyake, Hanako O. Ikeda, Tatsuya Yamada, Shin Kadomoto, Akihito Uji, and Akitaka Tsujikawa. 2020. "Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study" Journal of Clinical Medicine 9, no. 12: 4016. https://doi.org/10.3390/jcm9124016

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Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study

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