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Article

Asthma-Like Features and Anti-Asthmatic Drug Prescription in Children with Non-CF Bronchiectasis

1
Allergology and Pulmonology Unit, 3rd Paediatric Department, National and Kapodistrian University of Athens, 12462 Athens, Greece
2
2nd Radiology Department, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(12), 4009; https://doi.org/10.3390/jcm9124009
Received: 15 November 2020 / Revised: 3 December 2020 / Accepted: 8 December 2020 / Published: 11 December 2020
Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospectively reviewed. Episodes of dyspnea and wheezing, spirometric indices, total serum IgE, blood eosinophil counts, sensitization to aeroallergens, and air-trapping on expiratory CT scans, were recorded. The study included 65 children 1.5–16 years old, with non-CF bronchiectasis. Episodes of dyspnea or wheezing were reported by 22 (33.8%) and 23 (35.4%), respectively. Skin prick tests to aeroallergens (SPTs) were positive in 15 (23.0%) patients. Mosaic pattern on CT scans was observed in 37 (56.9%) patients. Dyspnea, presence of mosaic pattern, positive reversibility test, and positive SPTs were significantly correlated with the prescription of ICS. The prescription of ICS in children with bronchiectasis is more likely when there are certain asthma-like characteristics. The difficulty to set the diagnosis of real asthma in cases of bronchiectasis may justify the decision of clinicians to start an empirical trial with ICS in certain cases. View Full-Text
Keywords: inhaled corticosteroids; non-CF bronchiectasis; asthma; children inhaled corticosteroids; non-CF bronchiectasis; asthma; children
MDPI and ACS Style

Douros, K.; Sardeli, O.; Prountzos, S.; Galani, A.; Moriki, D.; Alexopoulou, E.; Priftis, K.N. Asthma-Like Features and Anti-Asthmatic Drug Prescription in Children with Non-CF Bronchiectasis. J. Clin. Med. 2020, 9, 4009. https://doi.org/10.3390/jcm9124009

AMA Style

Douros K, Sardeli O, Prountzos S, Galani A, Moriki D, Alexopoulou E, Priftis KN. Asthma-Like Features and Anti-Asthmatic Drug Prescription in Children with Non-CF Bronchiectasis. Journal of Clinical Medicine. 2020; 9(12):4009. https://doi.org/10.3390/jcm9124009

Chicago/Turabian Style

Douros, Konstantinos, Olympia Sardeli, Spyridon Prountzos, Angeliki Galani, Dafni Moriki, Efthymia Alexopoulou, and Kostas N. Priftis 2020. "Asthma-Like Features and Anti-Asthmatic Drug Prescription in Children with Non-CF Bronchiectasis" Journal of Clinical Medicine 9, no. 12: 4009. https://doi.org/10.3390/jcm9124009

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