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Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)

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Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
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Department of Neurology, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
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Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35209, USA
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Center of Affective, Stress and Sleep Disorders (ZASS), University of Basel, Psychiatric Clinics (UPK), 4002 Basel, Switzerland
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Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah 67198-51351, Iran
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Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73441, Iran
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Department of Biostatistics and Epidemiology, Faculty of Health, North Khorasan University of Medical Sciences, Bojnurd 74877-94149, Iran
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Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences (KUMS), Kermanshah 67198-51351, Iran
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School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran 14117-13135, Iran
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Department of Sport, Exercise, and Health, Division of Sport Science and Psychosocial Health, University of Basel, 4051 Basel, Switzerland
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Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3604; https://doi.org/10.3390/jcm9113604
Received: 2 October 2020 / Revised: 5 November 2020 / Accepted: 6 November 2020 / Published: 9 November 2020
(This article belongs to the Section Immunology)
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory and autoimmune disorder that is associated with impaired vision, sensory loss, pain, fatigue, and spasms in the upper and lower limbs. Typically, persons with this disorder are also at higher risks of falls. Given this, the aims of the study were to compare the prevalence rates of falling for NMOSD cases and healthy controls (HCs), and to predict falling in the former group based on sociodemographic, psychological, and illness-related factors. Method: A total of 95 adults with NMOSD (Mean age = 34.89 years; 70.5% females) and 100 matched HCs took part in the study. All participants completed a series of questionnaires covering sociodemographic information and falling rates. The NMOSD individuals also reported on disease duration, pain, fatigue, and fear of falling, while their balance performance was objectively assessed. Results: Compared to healthy controls, the NMOSD cases had a 2.5-fold higher risk of falling. In this latter group, higher scores for pain, fatigue, fear of falling, and higher EDSS scores were distinguished between fallers and non-fallers, and objective balance skills had no predictive value. Conclusions: Compared to healthy controls, NMOSD sufferers had a 2.5-fold higher risk of experiencing falls. In this group, disease impairments (EDSS, fatigue, pain) predicted falling. Specific interventions such as regular resistance training might reduce the risk of falling. View Full-Text
Keywords: inflammatory disease; neuromyelitis optica spectrum disorder; falling; predictors; pain; fatigue; balance inflammatory disease; neuromyelitis optica spectrum disorder; falling; predictors; pain; fatigue; balance
MDPI and ACS Style

Barzegar, M.; Sadeghi Bahmani, D.; Mirmosayyeb, O.; Azarbayejani, R.; Afshari-Safavi, A.; Vaheb, S.; Nehzat, N.; Dana, A.; Shaygannejad, V.; Motl, R.W.; Brand, S. Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD). J. Clin. Med. 2020, 9, 3604. https://doi.org/10.3390/jcm9113604

AMA Style

Barzegar M, Sadeghi Bahmani D, Mirmosayyeb O, Azarbayejani R, Afshari-Safavi A, Vaheb S, Nehzat N, Dana A, Shaygannejad V, Motl RW, Brand S. Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD). Journal of Clinical Medicine. 2020; 9(11):3604. https://doi.org/10.3390/jcm9113604

Chicago/Turabian Style

Barzegar, Mahdi, Dena Sadeghi Bahmani, Omid Mirmosayyeb, Reyhaneh Azarbayejani, Alireza Afshari-Safavi, Saeed Vaheb, Nasim Nehzat, Afshin Dana, Vahid Shaygannejad, Robert W. Motl, and Serge Brand. 2020. "Higher Disease and Pain Severity and Fatigue and Lower Balance Skills Are Associated with Higher Prevalence of Falling among Individuals with the Inflammatory Disease of Neuromyelitis Optica Spectrum Disorder (NMOSD)" Journal of Clinical Medicine 9, no. 11: 3604. https://doi.org/10.3390/jcm9113604

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