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Article

The Impact of Epstein-Barr Virus Infection on Juvenile Idiopathic Arthritis Activity and Patient’s Response to Treatment

1
Department of Paediatric Pulmonology and Rheumatology, Medical University of Lublin, 20-093 Lublin, Poland
2
Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, 20-093 Lublin, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(11), 3453; https://doi.org/10.3390/jcm9113453
Received: 4 October 2020 / Revised: 15 October 2020 / Accepted: 23 October 2020 / Published: 27 October 2020
This study aimed to investigate the relationship between Epstein-Barr virus (EBV) infection and the onset of juvenile idiopathic arthritis (JIA), disease activity, and response to treatment. The study included 44 children with JIA, 23 children with different types of arthritis, and 44 controls. We measured EBV infection markers, including the EBV DNA load and the concentration of antibodies to viral antigens, at disease onset, before treatment. Six months after JIA diagnosis and the initiation of treatment patients with anti-viral capsid antigen IgG had a higher disease activity and worse response to treatment than patients without previous infection. After six months of treatment, the probability of disease inactivity in children without a history of EBV infection was almost 6.5 times greater than in a child with a history of infection. Furthermore, the probability of a better response after six months of treatment in a child with a history of EBV infection was more than five times smaller than in a child without infection. A past EBV infection can have a negative effect on achieving disease remission and may be associated with a worse response to treatment. Our results do not indicate the need for routine assessment of EBV infection markers in patients with JIA. View Full-Text
Keywords: EBV; juvenile idiopathic arthritis; arthritis EBV; juvenile idiopathic arthritis; arthritis
MDPI and ACS Style

Opoka-Winiarska, V.; Grywalska, E.; Sobiesiak, A.; Roliński, J. The Impact of Epstein-Barr Virus Infection on Juvenile Idiopathic Arthritis Activity and Patient’s Response to Treatment. J. Clin. Med. 2020, 9, 3453. https://doi.org/10.3390/jcm9113453

AMA Style

Opoka-Winiarska V, Grywalska E, Sobiesiak A, Roliński J. The Impact of Epstein-Barr Virus Infection on Juvenile Idiopathic Arthritis Activity and Patient’s Response to Treatment. Journal of Clinical Medicine. 2020; 9(11):3453. https://doi.org/10.3390/jcm9113453

Chicago/Turabian Style

Opoka-Winiarska, Violetta, Ewelina Grywalska, Aleksandra Sobiesiak, and Jacek Roliński. 2020. "The Impact of Epstein-Barr Virus Infection on Juvenile Idiopathic Arthritis Activity and Patient’s Response to Treatment" Journal of Clinical Medicine 9, no. 11: 3453. https://doi.org/10.3390/jcm9113453

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