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Article

SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study

1
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy
2
Department of Medicine, ARNAS Civico, Unità Operativa Malattie Infettive, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Both Authors contributed equally.
Both Authors contributed equally.
J. Clin. Med. 2020, 9(10), 3315; https://doi.org/10.3390/jcm9103315
Received: 23 September 2020 / Revised: 10 October 2020 / Accepted: 13 October 2020 / Published: 15 October 2020
The course of SARS-CoV-2 infection ranges from asymptomatic to a multiorgan disease. In this observational study, we investigated SARS-CoV-2 infected subjects with defined outcomes, evaluating the relationship between viral load and single nucleotide polymorphisms of genes codifying for IFNλs (interferon). The study enrolled 381 patients with laboratory-confirmed SARS-CoV-2 infection. For each patient, a standardized form was filled including sociodemographic variables and clinical outcomes. The host’s gene polymorphisms (IFNL3 rs1297860 C/T and INFL4 rs368234815 TT/ΔG) and RtReal-Time PCR cycle threshold (PCR Ct) value on SARS-CoV-2 were assessed on nasal, pharyngeal or nasopharyngeal swabs. Higher viral loads were found in patients aged > 74 years and homozygous mutant polymorphisms DG in IFNL4 (adj-OR = 1.16, 95% CI = 1.01–1.34 and adj-OR = 1.24, 95% CI = 1.09–1.40, respectively). After adjusting for age and sex, a statistically significantly lower risk of hospitalization was observed in subjects with higher RtReal-Time PCR cycle threshold values (adj-OR = 0.95, 95% CI = 0.91, 0.99; p = 0.028). Our data support the correlation between SARS-CoV-2 load and disease severity, and suggest that IFNλ polymorphisms could affect the ability of the host to modulate viral infection without a clear impact on the outcome of COVID-19. View Full-Text
Keywords: SARS-CoV-2; COVID-19 outcomes; viral load; single nucleotide polymorphisms; IFNλs SARS-CoV-2; COVID-19 outcomes; viral load; single nucleotide polymorphisms; IFNλs
MDPI and ACS Style

Amodio, E.; Pipitone, R.M.; Grimaudo, S.; Immordino, P.; Maida, C.M.; Prestileo, T.; Restivo, V.; Tramuto, F.; Vitale, F.; Craxì, A.; Casuccio, A. SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study. J. Clin. Med. 2020, 9, 3315. https://doi.org/10.3390/jcm9103315

AMA Style

Amodio E, Pipitone RM, Grimaudo S, Immordino P, Maida CM, Prestileo T, Restivo V, Tramuto F, Vitale F, Craxì A, Casuccio A. SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study. Journal of Clinical Medicine. 2020; 9(10):3315. https://doi.org/10.3390/jcm9103315

Chicago/Turabian Style

Amodio, Emanuele, Rosaria M. Pipitone, Stefania Grimaudo, Palmira Immordino, Carmelo M. Maida, Tullio Prestileo, Vincenzo Restivo, Fabio Tramuto, Francesco Vitale, Antonio Craxì, and Alessandra Casuccio. 2020. "SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study" Journal of Clinical Medicine 9, no. 10: 3315. https://doi.org/10.3390/jcm9103315

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