Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Techniques
2.3. Image Review and Flow Calculation
- Vessel identification: In the 2D image frame, the target artery in the flow ROI (region of interest) was centered. The size of the flow ROI was adjusted so that the artery diameter was 1/2–2/3 of the size of the flow ROI. The cut on the 3D image was confirmed to be on the correct artery and perpendicular to the artery’s longitudinal axis. We corrected the measurement with one background ROI to avoid the eddy current effect while image distortion happened.
- Vessel contour edit: The artery contours (automatically drawn) were checked to determine if they accurately tracked the artery borders on the magnitude, phase, and/or velocity images; were then modified, as necessary, to ensure that they tracked the velocity images.
- Flow check: Motion correction was applied if necessary.
- VENC check: It was checked to see if improper VENC was detected.
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Variable, Unit | Time 1 | Time 2 |
---|---|---|
Group | ||
Healthy | 22 (73%) | - |
Post-stroke | 8 (27%) | - |
Sex | ||
Male | 14 (47%) | - |
Female | 16 (53%) | - |
Age, years | 46.9 ± 14.4 (23.0–69.0) | - |
<50 | 15 (50%) | - |
>50 | 15 (50%) | - |
Systolic blood pressure, mm Hg | 120.8 ± 17.3 (92.5–161.0) | 120.2 ± 14.3 (94.5–158.0) |
Diastolic blood pressure, mm Hg | 74.8 ± 13.8 (45.0–105.5) | 74.5 ± 11.3 (48.5–97.0) |
Mean arterial pressure, mm Hg | 90.1 ± 14.5 (67.2–121.0) | 89.8 ± 11.4 (64.7–113.7) |
Pulse rate, beats/min | 72.6 ± 11.7 (49.8–103.4) | 72.7 ± 18 (51–134.3) |
Mean volume blood flow, mL/min | 755.5 ± 173.4 (472.5–972.5) | 726.8 ± 146.9 (515–1007) |
Variable, Unit | Time 1 | Time 2 |
---|---|---|
Operator A | ||
LVA | 124.8 ± 48.5 (37–215) | 121.1 ± 50.9 (34–251) |
RVA | 78.6 ± 36.1 (16–144) | 78.3 ± 26.7 (26–134) |
BA | 148.2 ± 60.3 (25–306) | 140.7 ± 50.8 (14–243) |
LPCA | 88.2 ± 29.9 (46–188) | 79.7 ± 18.7 (49–118) |
RPCA | 83.2 ± 23.5 (41–141) | 77.8 ± 21.8 (42–126) |
LMCA | 163.6 ± 50.8 (81–298) | 156.7 ± 38.9 (98–223) |
RMCA | 172.3 ± 42.6 (91–285) | 161.8 ± 35.9 (93–226) |
pLACA | 111.6 ± 29.9 (60–208) | 103.5 ± 25.1 (54–159) |
pRACA | 101.1 ± 30.3 (29–168) | 96.8 ± 41.9 (14–222) |
LICA | 271.5 ± 79.4 (142–477) | 256.1 ± 54.1 (155–361) |
RICA | 273.8 ± 81.5 (103–446) | 265.8 ± 66.1 (148–419) |
dLACA | 79.9 ± 23.1 (42–135) | 74.7 ± 18.3 (41–112) |
dRACA | 69.3 ± 26.1 (34–139) | 66.5 ± 16.4 (31–103) |
Operator B | ||
LVA | 129.3 ± 54 (33–257) | 123.9 ± 52.6 (35–235) |
RVA | 84 ± 37.5 (39–169) | 87.9 ± 32.2 (41–157) |
BA | 149.2 ± 64.1 (16–261) | 142.4 ± 51.8 (28–232) |
LPCA | 81.3 ± 28.1 (43–177) | 80.5 ± 20.4 (39–111) |
RPCA | 76 ± 24 (39–132) | 80.7 ± 21.1 (36–122) |
LMCA | 158.1 ± 52.4 (30–298) | 157.5 ± 50.2 (72–309) |
RMCA | 164.3 ± 41.2 (87–265) | 167.7 ± 49.8 (98–335) |
pLACA | 110.7 ± 34 (57–202) | 106.7 ± 31.5 (48–202) |
pRACA | 97.1 ± 36.4 (25–172) | 94.4 ± 32.5 (32–159) |
LICA | 273.7 ± 91.3 (152–629) | 247 ± 49.4 (144–312) |
RICA | 276 ± 73.6 (141–498) | 257.2 ± 72.7 (115–385) |
dLACA | 77.9 ± 27.4 (47–178) | 74.7 ± 23.7 (33–140) |
dRACA | 67.2 ± 25 (21–129) | 70.8 ± 29.4 (35–181) |
Artery | Operator A | Operator B | Average Measure * | SEM * | MDC95% | |||
---|---|---|---|---|---|---|---|---|
ICC (95% CI) | P-Value | ICC (95% CI) | P-Value | ICC (95% CI) | P-Value | (mL/min) | (mL/min) | |
LVA | 0.85 (0.689–0.931) | <0.001 | 0.773 (0.551–0.893) | <0.001 | 0.925 (0.83–0.967) | <0.001 | 20.1 | 55.7 |
RVA | 0.794 (0.573–0.907) | <0.001 | 0.883 (0.749–0.948) | <0.001 | 0.954 (0.892–0.981) | <0.001 | 12.0 | 33.3 |
BA | 0.799 (0.6–0.904) | <0.001 | 0.773 (0.555–0.891) | <0.001 | 0.893 (0.761–0.952) | <0.001 | 24.2 | 67.1 |
LPCA | 0.568 (0.231–0.784) | 0.001 | 0.695 (0.42–0.853) | <0.001 | 0.837 (0.63–0.928) | <0.001 | 11.6 | 32.2 |
RPCA | 0.548 (0.185–0.78) | 0.003 | 0.676 (0.39–0.843) | <0.001 | 0.841 (0.625–0.933) | <0.001 | 12.3 | 34.1 |
LMCA | 0.75 (0.518–0.88) | <0.001 | 0.888 (0.767–0.948) | <0.001 | 0.881 (0.73–0.948) | <0.001 | 18.2 | 50.4 |
RMCA | 0.523 (0.177–0.753) | 0.003 | 0.638 (0.34–0.82) | <0.001 | 0.749 (0.43–0.889) | 0.001 | 23.2 | 64.3 |
pLACA | 0.65 (0.358–0.826) | <0.001 | 0.858 (0.712–0.933) | <0.001 | 0.855 (0.677–0.935) | <0.001 | 12.8 | 35.5 |
pRACA | 0.786 (0.572–0.9) | <0.001 | 0.861 (0.718–0.934) | <0.001 | 0.936 (0.856–0.972) | <0.001 | 14.0 | 38.8 |
LICA | 0.687 (0.415–0.846) | <0.001 | 0.624 (0.318–0.812) | <0.001 | 0.841 (0.645–0.929) | <0.001 | 31.7 | 87.9 |
RICA | 0.787 (0.58–0.899) | <0.001 | 0.554 (0.22–0.772) | 0.001 | 0.880 (0.733–0.946) | <0.001 | 34.7 | 96.2 |
dLACA | 0.482 (0.124–0.729) | 0.005 | 0.141 (−0.262–0.502) | 0.25 | 0.641 (0.185–0.842) | 0.007 | 13.8 | 38.3 |
dRACA | 0.526 (0.181–0.755) | 0.002 | 0.687 (0.415–0.847) | <0.001 | 0.796 (0.537–0.91) | <0.001 | 13.0 | 36.0 |
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Chang, K.-H.; Lee, Y.-H.; Chen, C.-Y.; Lin, M.-F.; Lin, Y.C.; Chen, J.-H.; Chan, W.P. Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI. J. Clin. Med. 2020, 9, 3099. https://doi.org/10.3390/jcm9103099
Chang K-H, Lee Y-H, Chen C-Y, Lin M-F, Lin YC, Chen J-H, Chan WP. Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI. Journal of Clinical Medicine. 2020; 9(10):3099. https://doi.org/10.3390/jcm9103099
Chicago/Turabian StyleChang, Kwang-Hwa, Yuan-Hao Lee, Chia-Yuen Chen, Ming-Fang Lin, Ying Chin Lin, Jyh-Horng Chen, and Wing P. Chan. 2020. "Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI" Journal of Clinical Medicine 9, no. 10: 3099. https://doi.org/10.3390/jcm9103099