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Article

Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans

1
Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland
2
Department of Invasive Cardiology, Teaching University Hospital of Bialystok, 15-276 Bialystok, Poland
3
Department of Cardiology, Teaching University Hospital of Bialystok, 15-276 Bialystok, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 74; https://doi.org/10.3390/jcm9010074
Received: 15 December 2019 / Revised: 23 December 2019 / Accepted: 24 December 2019 / Published: 27 December 2019
(This article belongs to the Section Cardiology)
Background: Natriuretic peptides (NPs), including brain natriuretic peptide (BNP), are neurohormones involved in the regulation of water-sodium balance and the maintenance of cardiovascular homeostasis. A higher concentration of NPs is observed in females, but the mechanism behind this difference has not been fully elucidated. Methods: Randomly chosen 255 volunteers from the general population were examined. Overall, 196 people without severe cardiovascular disease were included (mean age 48 years, 35.7% male). A comprehensive assessment was performed, including anthropometric measurements, N-terminal pro-brain natriuretic peptide (NT-proBNP), total testosterone (TT) and sex hormone-binding globulin (SHBG) concentration, transthoracic echocardiography (ECHO), and body composition analysis by direct dual-energy X-ray absorptiometry (DEXA). The univariate analysis adjusted by the known affecting factors determined which measurements were independently associated with NT-proBNP concentration. Results: NT-proBNP concentration was positively associated with gynoid fat mass, gynoid/total fat (G/TF) mass index, SHBG and negatively with android/gynoid (A/G) fat mass index, TT and calculated free testosterone (CFT) concentrations. Furthermore, body composition parameters remained independently associated with NT-proBNP levels even after adjusting for CFT and SHBG. Conclusion: In the population without severe cardiovascular disease, the NT-proBNP concentration is independently associated with lower availability of testosterone and higher gynoid fat distribution, which may explain higher NPs levels in females. View Full-Text
Keywords: natriuretic peptide; gynoid fat tissue; sex; population studies natriuretic peptide; gynoid fat tissue; sex; population studies
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MDPI and ACS Style

Chlabicz, M.; Jamiołkowski, J.; Paniczko, M.; Sowa, P.; Łapińska, M.; Szpakowicz, M.; Jurczuk, N.; Kondraciuk, M.; Raczkowski, A.; Sawicka, E.; Kamiński, K.A. Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans. J. Clin. Med. 2020, 9, 74. https://doi.org/10.3390/jcm9010074

AMA Style

Chlabicz M, Jamiołkowski J, Paniczko M, Sowa P, Łapińska M, Szpakowicz M, Jurczuk N, Kondraciuk M, Raczkowski A, Sawicka E, Kamiński KA. Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans. Journal of Clinical Medicine. 2020; 9(1):74. https://doi.org/10.3390/jcm9010074

Chicago/Turabian Style

Chlabicz, Małgorzata, Jacek Jamiołkowski, Marlena Paniczko, Paweł Sowa, Magda Łapińska, Małgorzata Szpakowicz, Natalia Jurczuk, Marcin Kondraciuk, Andrzej Raczkowski, Emilia Sawicka, and Karol A. Kamiński 2020. "Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans" Journal of Clinical Medicine 9, no. 1: 74. https://doi.org/10.3390/jcm9010074

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