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Open AccessArticle

Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

1
College of Pharmacy, Gachon University 191, Hambakmoero, Yeonsu-gu, Incheon 21936, Korea
2
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Korea
3
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
4
Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon 21936, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2020, 9(1), 59; https://doi.org/10.3390/jcm9010059
Received: 14 November 2019 / Revised: 12 December 2019 / Accepted: 23 December 2019 / Published: 26 December 2019
(This article belongs to the Special Issue Bioactive Phytochemicals in Health and Disease)
Ulmus parvifolia is one of the medicinal plants used traditionally for treatment of wounds. We intended to investigate the wound healing effect of the powder of Ulmus parvifolia (UP) root bark in a mouse wound healing model. We also determined the mechanisms of effects of U. parvifolia in skin and skin wound healing effects using a keratinocyte model. Animal experiments showed that the wound lesions in the mice decreased with 200 mesh U. parvifolia root bark powder and were significantly reduced with treatment by UP, compared with those treated with Ulmus macrocarpa (UM). Results from in vitro experiments also revealed that UP extract promoted the migration of human skin keratinocytes. UP powder treatment upregulated the expression of the matrix metalloproteinase-2 and -9 protein and significantly increased transforming growth factor (TGF)-β levels. We confirmed that topical administration of the bark powder exerted a significant effect on skin wound healing by upregulating the expression of MMP and transforming growth factor-β. Our study suggests that U. parvifolia may be a potential candidate for skin wound healing including epidermal skin rejuvenation. View Full-Text
Keywords: Ulmus parvifolia; wound healing; matrix metalloproteinase; transforming growth factor; skin rejuvenation Ulmus parvifolia; wound healing; matrix metalloproteinase; transforming growth factor; skin rejuvenation
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Kang, M.C.; Yumnam, S.; Park, W.S.; So, H.M.; Kim, K.H.; Shin, M.C.; Ahn, M.-J.; Kim, S.Y. Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β. J. Clin. Med. 2020, 9, 59.

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