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Open AccessArticle

Influence of Pneumonia on the Survival of Patients with COPD

Pulmonology Service, Gregorio Marañón University General Hospital, 28007 Madrid, Spain
Pulmonology Section, Infanta Leonor University Hospital, 28031 Madrid, Spain
Research Support Service, Gregorio Marañón Health Research Institute, 28007 Madrid, Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 230;
Received: 16 December 2019 / Revised: 6 January 2020 / Accepted: 13 January 2020 / Published: 15 January 2020
(This article belongs to the Section Pulmonology)
Background: Pneumonia is a frequent infection. Chronic obstructive pulmonary disease (COPD) can present with comorbidities, including pneumonia. It is known that COPD worsens the evolution of pneumonia, but few studies describe the impact of pneumonia on COPD evolution. This study analyzes the influence of pneumonia on the survival of COPD patients. Methods: Observational study of a cohort of 273 patients with COPD who attended spirometry in 2011, with a prospective follow-up of six years. Patients were divided into two groups according to their acquisition of pneumonia during follow-up. The difference in survival between the two groups was analyzed. Results: Survival was lower in the group with pneumonia compared with that without pneumonia (p = 0.000), both globally and after stratification by COPD phenotype. Pneumonia (Hazard Ratio -HR- 2.65; 95% Confidence Interval -CI- 1.57–4.48), advanced age (HR 1.08; 95% CI 1.03–1.09), and high Charlson index (HR 1.31; 95% CI 1.17–1.47) were identified as risk factors independently associated with mortality, while a high body mass index (HR 0.92; 95% CI 0.87–0.96) was identified as a protective factor. Conclusions: Pneumonia is associated with worse prognosis in COPD patients. It is important to take into account this comorbidity for a comprehensive care of these patients. View Full-Text
Keywords: chronic obstructive pulmonary disease (COPD); respiratory infections; pneumonia; survival chronic obstructive pulmonary disease (COPD); respiratory infections; pneumonia; survival
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Ji, Z.; Hernández Vázquez, J.; Bellón Cano, J.M.; Gallo González, V.; Recio Moreno, B.; Cerezo Lajas, A.; Puente Maestu, L.; de Miguel Díez, J. Influence of Pneumonia on the Survival of Patients with COPD. J. Clin. Med. 2020, 9, 230.

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