Next Article in Journal
Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation
Previous Article in Journal
Development and Disease-Dependent Dynamics of Spermatogonial Subpopulations in Human Testicular Tissues
Open AccessArticle

Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction

1
Department of Urology, La Croix du Sud Hospital, 52, chemin de Ribaute, 31130 Quint Fonsegrives, France
2
Department of Urology, Institut Universitaire du Cancer Toulouse—Oncopole, 31000 Toulouse, France
3
Department of Radiology, CHU La Pitié Salpétrière/Tenon, Sorbonne Université, 75005 Paris, France
4
Department of Urology, CHU Toulouse, 31000 Toulouse, France
5
Department of Radiology, Institut Universitaire du Cancer Toulouse—Oncopole, 31000 Toulouse, France
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 225; https://doi.org/10.3390/jcm9010225
Received: 19 December 2019 / Revised: 7 January 2020 / Accepted: 10 January 2020 / Published: 15 January 2020
(This article belongs to the Section Nephrology & Urology)
Background: To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. Materials and Methods: The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fusion TB. Endpoints were the upgrading and concordance rates between TB and RP specimens. Results: Upgrading rate after TB was 40.6%. Patients with upgrading had lower PIRADS (Prostate Imaging-Reporting and Data System) scores (p < 0.001), smaller lesion size (p = 0.017), fewer TB cores (p < 0.001), and lower TB density (p = 0.015) compared with cases with grade concordance. There was a significant continuous improvement in upgrading rate when TB core number per lesion increased from 56.3% to 25.6% when <2 or ≥5 TB cores were taken, respectively (p = 0.002). The minimal TB number per lesion to reduce upgrading risk to approximately 30%was 4 in PIRADS 3, and 3 in PIRADS 4–5 cases. Conclusions: Grade group prediction by TB is significantly improved by higher PIRADS score, larger lesion size, and increased TB per lesion. At least four TB cores should be taken in PIRADS 3 score lesions, whereas three cores seem enough in PIRADS 4–5 cases to improve GG prediction and limit upgrading risk. View Full-Text
Keywords: prostate cancer; radical prostatectomy; upgrading; biopsy; targeted biopsies; MRI; fusion biopsies; systematic biopsies prostate cancer; radical prostatectomy; upgrading; biopsy; targeted biopsies; MRI; fusion biopsies; systematic biopsies
Show Figures

Figure 1

MDPI and ACS Style

Ploussard, G.; Beauval, J.-B.; Renard-Penna, R.; Lesourd, M.; Manceau, C.; Almeras, C.; Gautier, J.-R.; Loison, G.; Portalez, D.; Salin, A.; Soulié, M.; Tollon, C.; Malavaud, B.; Roumiguié, M. Assessment of the Minimal Targeted Biopsy Core Number per MRI Lesion for Improving Prostate Cancer Grading Prediction. J. Clin. Med. 2020, 9, 225.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop