Next Article in Journal
Characterization and Analysis of the Skin Microbiota in Rosacea: Impact of Systemic Antibiotics
Previous Article in Journal
Chimeric Antigen Receptor T-Cell Therapy for Colorectal Cancer
Open AccessArticle

The Immunomodulary Effects of Systematic Exercise in Older Adults and People with Parkinson’s Disease

1
Department of Clinical Rehabilitation, Faculty of Motor Rehabilitation, University of Physical Education in Krakow, 31–571 Krakow, Poland
2
Institute of Physiotherapy, Faculty of Health Science, Jagiellonian University Medical College, 31–126 Krakow, Poland
3
Department of Physiology and Biochemistry, Faculty of Physical Education and Sport, University of Physical Education in Krakow, 31–571 Krakow, Poland
4
Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, 31–503 Krakow, Poland
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 184; https://doi.org/10.3390/jcm9010184 (registering DOI)
Received: 18 December 2019 / Revised: 5 January 2020 / Accepted: 7 January 2020 / Published: 9 January 2020
(This article belongs to the Section Clinical Neurology)
We sought to investigate whether regular balance training of moderate intensity (BT) has an effect on changes in selected cytokines, neurotrophic factors, CD200 and fractalkine in healthy older adults and participants with Parkinson’s disease (PD). Sixty-two subjects were divided into groups depending on experimental intervention: (1) group of people with PD participating in BT (PDBT), (2) group of healthy older people participating in BT (HBT), (3,4) control groups including healthy individuals (HNT) and people with PD (PDNT). Blood samples were collected twice: before and after 12 weeks of balance exercise (PDBT, HBT), or 12 weeks apart (PDNT, HNT). The study revealed significant increase of interleukin10 (PDBT, p = 0.026; HBT, p = 0.011), β-nerve growth factor (HBT, p = 0.002; PDBT, p = 0.016), transforming growth factor-β1 (PDBT, p = 0.018; HBT, p < 0.004), brain-derived neurotrophic factor (PDBT, p = 0.011; HBT, p < 0.001) and fractalkine (PDBT, p = 0.045; HBT, p < 0.003) concentration only in training groups. In PDBT, we have found a significant decrease of tumor necrosis factor alpha. No training effect on concentration of interleukin6, insulin-like growth factor 1 and CD200 was observed in both training and control groups. Regular training can modulate level of inflammatory markers and induce neuroprotective mechanism to reduce the inflammatory response. View Full-Text
Keywords: inflammation; regular training; neurological disorders; older people inflammation; regular training; neurological disorders; older people
Show Figures

Figure 1

MDPI and ACS Style

Szymura, J.; Kubica, J.; Wiecek, M.; Pera, J. The Immunomodulary Effects of Systematic Exercise in Older Adults and People with Parkinson’s Disease. J. Clin. Med. 2020, 9, 184.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop