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Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

1
Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
2
Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan
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Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
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Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu 501-1194, Japan
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Department of Clinical Laboratory, Gifu University Hospital, Gifu 501-1194, Japan
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Medical Health Check-up Center, Asahi University Hospital, Gifu 500-8523, Japan
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Department of Internal Medicine, Asahi University School of Dentistry, Mizuho 501-0223, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to the manuscript.
J. Clin. Med. 2019, 8(9), 1320; https://doi.org/10.3390/jcm8091320
Received: 27 June 2019 / Revised: 20 August 2019 / Accepted: 24 August 2019 / Published: 27 August 2019
(This article belongs to the Section Vascular Medicine)
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration. View Full-Text
Keywords: endothelial disorders; glycocalyx injury; syndecan-1; nonlinear regression endothelial disorders; glycocalyx injury; syndecan-1; nonlinear regression
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Oda, K.; Okada, H.; Suzuki, A.; Tomita, H.; Kobayashi, R.; Sumi, K.; Suzuki, K.; Takada, C.; Ishihara, T.; Suzuki, K.; Kano, S.; Kondo, K.; Iwashita, Y.; Yano, H.; Zaikokuji, R.; Sampei, S.; Fukuta, T.; Kitagawa, Y.; Okamoto, H.; Watanabe, T.; Kawaguchi, T.; Kojima, T.; Deguchi, F.; Miyazaki, N.; Yamada, N.; Doi, T.; Yoshida, T.; Ushikoshi, H.; Yoshida, S.; Takemura, G.; Ogura, S. Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination. J. Clin. Med. 2019, 8, 1320.

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