Meta-Analysis of Differential miRNA Expression after Bariatric Surgery
Abstract
:1. Introduction
2. Methods
2.1. Search Strategies
2.2. Study Selection
2.3. Data Collection Process
2.4. Synthesis of Results
3. Results
3.1. Selected Studies for the Meta-Analysis
3.2. Differential Expression of miRNA before and after Surgery
3.3. Pathway Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study | Year | Country | Sample Size | Sex (Males/Females) |
---|---|---|---|---|
Human studies (comparing before vs. after bariatric surgery) | ||||
Ortega et al. [29] | 2013 | Spain | 22 | 5/17 |
Alkandari et al. [30] | 2018 | UK | 9 | 4/5 |
Atkin et al. [31] | 2019 | USA | 29 | 9/20 |
Bae et al. [32] | 2019 | South Korea | 12 | Unspecified |
Blum et al. [33] | 2017 | Israel | 21 | 14/7 |
Hohensinner et al. [36] | 2018 | Austria | 58 | 17/41 |
Hubal et al. [37] | 2017 | USA | 6 | 0/6 |
Hulsmans et al. [38] | 2012 | Belgium | 21 | 7/14 |
Lirun et al. [40] | 2015 | China | 18 | 4/11 |
Mysore et al. [41] | 2017 | Spain | 22 | 0/22 |
Ortega et al. [42] | 2015 | Spain | 25 | 0/25 |
Ortega et al. [43] | 2015 | Spain | 9 | 0/9 |
Wang et al. [44] | 2018 | China | 124 | 46/78 |
Animal studies (comparing bariatric vs sham surgery) | ||||
Guo et al. [34] | 2016 | China | 35 | 35/0 |
Wei et al. [35] | 2018 | China | 45 | 45/0 |
Kwon et al. [39] | 2015 | South Korea | 25 | 25/0 |
Wu et al. [45] | 2015 | UK | 12 | 12/0 |
Study | Tissue | Isolation | Platform | Normalization |
---|---|---|---|---|
Human studies | ||||
Ortega et al. [29] | Plasma | mirVana PARIS Isolation Kit | TaqMan array miRNA cards in a subset and qPCR in the final sample | Geometric mean of six miRNAs (hsa-miR-106a-5p, hsa-miR-146a-5p, hsa-miR-19b-3p, hsa-miR-223-3p, hsa-miR-186-5p, hsa-miR-199a-3p) |
Alkandari et al. [30] | Plasma | mirVana PARIS Isolation Kit | miRCURY qPCR panel | Four miRNAs (hsa-miR-223-3p, hsa-miR-26a-5p, hsa-miR-101-3p, and hsa-miR-19a-3p) |
Atkin et al. [31] | Plasma | miRCURY RNA Isolation kit | qPCR and a FANTOM miRNA atlas [68] | Global mean |
Bae et al. [32] | Exosome | miRNeasy Mini Kit | Small RNA sequencing | Relative log expression using DESeq2 |
Blum et al. [33] | Serum | miRNeasy serum/plasma kit | RNA sequencing in a subset and qPCR in the final sample | hsa-miR-451a |
Hohensinner et al. [36] | Plasma | miRNA tissue lysis kit | qPCR | RNA spike-in |
Hubal et al. [37] | Exosome | mirVANA miRNA Isolation Kit | GeneChip miRNA 4.0 Array | RMA algorithm |
Hulsmans et al. [38] | Monocytes | TRIzol reagent | qPCR | RNU5G |
Lirun et al. [40] | Plasma | mirVana RNA Isolation Kit | GeneChip miRNA 3.0 Array | RMA algorithm |
Mysore et al. [41] | Subcutaneous Adipose Tissue (SAT) | miRNeasy Mini kit | qPCR | RNU44 |
Ortega et al. [42] | SAT | miRNeasy Mini Kit | GeneChip miRNA 3.0 array in a subset and qPCR in the final sample | RMA algorithm and RNU48 |
Ortega et al. [43] | SAT | miRNeasy Mini Kit | qPCR | RNU6B |
Wang et al. [44] | Circulating Endothelial Progenitor Cells | High Pure RNA kit | qPCR | RNU6 |
Animal studies | ||||
Guo et al. [34] | Liver | TRIzol reagent | miProfile Customized Rat qPCR arrays | 5S rRNA and RsnRNA U6 |
Wei et al. [35] | Liver | TRIzol reagent | miProfile Customized Rat qPCR arrays | 5S rRNA, RsnRNA U6, rno-miR-25, and rno-miR-186 |
Kwon et al. [39] | Hypothalamus, Heart, and Liver | Unspecified | Agilent Rat miRNA 8x15k microarray for hypothalamus and heart samples, then qPCR for liver and validation | Whole-array and RNU6 |
Wu et al. [45] | Plasma and Liver | mirVANA PARIS RNA Isolation kit | TaqMan Array Rodent Card | RNU6-1, RNU6-2, rno-miR-16-5p, rno-miR-223-3p, mmu-miR-1937b |
Study | Year | Bariatric Surgery Type | Time of Observation after Surgery |
---|---|---|---|
Human studies | |||
Ortega et al. [29] | 2013 | RYGB | 12 months |
Alkandari et al. [30] | 2018 | RYGB | 1, 3, 6, 9, and 12 months |
Atkin et al. [31] | 2019 | RYGB | 21 days |
Bae et al. [32] | 2019 | RYGB and SG | 6 months |
Blum et al. [33] | 2017 | SG | 3 months |
Hohensinner et al. [36] | 2018 | RYGB | 24 months |
Hubal et al. [37] | 2017 | RYGB | 12 months |
Hulsmans et al. [38] | 2012 | RYGB | 3 months |
Lirun et al. [40] | 2015 | RYGB | 3 months |
Mysore et al. [41] | 2017 | RYGB | 24 months |
Ortega et al. [42] | 2015 | RYGB | 24 months |
Ortega et al. [43] | 2015 | RYGB | 24 months |
Wang et al. [44] | 2018 | Not specified | 3 months |
Animal studies | |||
Guo et al. [34] | 2016 | DJB and SG | 2, 4, 8 weeks |
Wei et al. [35] | 2018 | DJB | 2, 4, 8 weeks |
Kwon et al. [39] | 2015 | RYGB | 25 days |
Wu et al. [45] | 2015 | RYGB | 53 days |
miRNA | miRBase | References | Direction of Expression | No. of Subjects | Tissue | Time of Observation | |
---|---|---|---|---|---|---|---|
Group 1 miRNAs (same direction of expression after surgery in two or more studies) | |||||||
1 | hsa-miR-93-5p | MIMAT0000093 | Lirun [40] | − | 15 | Plasma | 3 months |
Alkandari [30] | 9 | Plasma | 3 months | ||||
2 | hsa-miR-106b-5p | MIMAT0000680 | Lirun [40] | − | 15 | Plasma | 3 months |
Alkandari [30] | 9 | Plasma | 3, 12 months | ||||
3 | hsa-let-7b-5p | MIMAT0000063 | Lirun [40] | − | 15 | Plasma | 3 months |
Alkandari [30] | 9 | Plasma | 3 months | ||||
4 | hsa-let-7i-5p | MIMAT0000415 | Lirun [40] | − | 15 | Plasma | 3 months |
Alkandari [30] | 9 | Plasma | 6, 9 months | ||||
Atkin [31] | 29 | Plasma | 21 days | ||||
5 | hsa-miR-16-5p | MIMAT0000069 | Lirun [40] | − | 15 | Plasma | 3 months |
Hubal [37] | 6 | Exosomes | 12 months | ||||
6 | hsa-miR-19b-3p | MIMAT0000074 | Ortega [43] | − | 9 | SAT | 24 months |
Lirun [40] | 15 | Plasma | 3 months | ||||
Ortega [29] | 22 | Plasma | 12 months | ||||
7 | hsa-miR-92a-3p | MIMAT0000092 | Lirun [40] | − | 15 | Plasma | 3 months |
Alkandari [30] | 9 | Plasma | 9, 12 months | ||||
8 | hsa-miR-222-3p | MIMAT0000279 | Ortega [29] | − | 22 | Plasma | 12 months |
Ortega [43] | 9 | SAT | 24 months | ||||
9 | hsa-miR-142-3p | MIMAT0000434 | Bae [32] | − | 12 | Exosome | 6 months |
Ortega [29] | 22 | Plasma | 12 months | ||||
10 | hsa-miR-140-5p | MIMAT0000431 | Bae [32] | − | 12 | Exosome | 6 months |
Ortega [29] | 22 | Plasma | 12 months | ||||
11 | hsa-miR-155-5p | MIMAT0000646 | Ortega [43] | − | 9 | SAT | 24 months |
Ortega [42] | 25 | SAT | 24 months | ||||
12 | rno-miR-320-3p | MIMAT0000903 | Wu [45] | − | 4 | Plasma | 53 days |
Wei [35] | 5 | liver | 2 months | ||||
13 | hsa-miR-320c | MIMAT0005793 | Atkin [31] | + | 29 | Plasma | 21 days |
Lirun [40] | 15 | Plasma | 3 months | ||||
14 | hsa-miR-7-5p | MIMAT0000252 | Atkin [31] | + | 29 | Plasma | 21 days |
Bae [32] | 12 | Exosome | 6 months | ||||
Group 2 miRNAs (overall same direction of expression after surgery in two or more studies) | |||||||
1 | hsa-miR-125b-5p | MIMAT0000423 | Ortega [29] | − | 22 | Plasma | 12 months |
Alkandari [30] | − | 9 | Plasma | 6, 9, 12 months | |||
Hubal [37] | + | 6 | Exosomes | 12 months | |||
2 | hsa-miR-130b-3p | MIMAT0000691 | Ortega [42] | − | 25 | SAT | 24 months |
Alkandari [30] | − | 9 | Plasma | 12 months | |||
Ortega [29] | + | 22 | Plasma | 12 months | |||
3 | hsa-miR-221-3p | MIMAT0000278 | Ortega [43] | − | 9 | SAT | 24 months |
Ortega [42] | − | 25 | SAT | 24 months | |||
Mysore [41] | − | 22 | SAT | 24 months | |||
Lirun [40] | − | 15 | Plasma | 3 months | |||
Ortega [29] | + | 22 | Plasma | 12 months | |||
4 | rno-miR-122-5p | MIMAT0000827 | Kwon [39] | − | 25 | heart | 25 days |
Kwon [39] | − | 25 | liver | 25 days | |||
Wu [45] | − | 4 | Plasma | 53 days | |||
Wu [45] | − | 8 | Liver | 53 days | |||
Kwon [39] | + | 25 | hypothalamus | 25 days | |||
5 | hsa-miR-146a-5p | MIMAT0000449 | Lirun [40] | − | 15 | Plasma | 3 months |
Ortega [43] | − | 9 | SAT | 24 months | |||
Ortega [29] | + | 22 | Plasma | 12 months | |||
6 | rno-miR-503-5p | MIMAT0003213 | Kwon [39] | + | 25 | hypothalamus | 25 days |
Kwon [39] | + | 25 | heart | 25 days | |||
Wei [35] | − | 4 | liver | 2 months | |||
Group 3 miRNAs (reported in at least two studies, but with no agreement in direction of expression) | |||||||
1 | hsa-miR-21-5p | MIMAT0000076 | Alkandari [30] | − | 9 | Plasma | 9, 12 months |
Ortega [29] | + | 22 | Plasma | 12 months | |||
2 | hsa-miR-33a-5p | MIMAT0000091 | Bae [32] | − | 12 | Exosome | 6 months |
Alkandari [30] | + | 9 | Plasma | 6 months | |||
3 | hsa-miR-320a-3p | MIMAT0000510 | Alkandari [30] | − | 9 | Plasma | 6, 9, 12 months |
Lirun [40] | + | 15 | Plasma | 3 months | |||
4 | hsa-miR-320b | MIMAT0005792 | Alkandari [30] | − | 9 | Plasma | 9 months |
Lirun [40] | + | 15 | Plasma | 3 months | |||
5 | hsa-miR-378a-3p | MIMAT0000732 | Alkandari [30] | − | 9 | Plasma | 6, 9, 12 months |
Lirun [40] | + | 15 | Plasma | 3 months | |||
6 | hsa-miR-103-3p | MIMAT0000101 | Lirun [40] | − | 15 | Plasma | 3 months |
Hubal [37] | + | 6 | Exosomes | 12 months | |||
7 | rno-miR-133b-3p | MIMAT0003126 | Wei [35] | − | 4 | liver | 2 months |
Kwon [39] | + | 25 | hypothalamus | 25 days | |||
8 | rno-miR-194-5p | MIMAT0000869 | Kwon [39] | − | 25 | heart | 25 days |
Guo [34] | + | 4 | liver | 2 months | |||
9 | hsa-miR-122-5p | MIMAT0000421 | Ortega [29] | − | 22 | Plasma | 12 months |
Blum [33] | + | 21 | Serum | 3 months | |||
10 | rno-miR-146a-5p | MIMAT0000852 | Wu [45] | − | 4 | Plasma | 53 days |
Kwon [39] | + | 25 | hypothalamus | 25 days | |||
11 | rno-miR-542-3p | MIMAT0003179 | Wei [35] | − | 4 | liver | 2 months |
Kwon [39] | + | 25 | hypothalamus | 25 days | |||
12 | hsa-miR-191-5p | MIMAT0000440 | Lirun [40] | − | 15 | Plasma | 3 months |
Bae [32] | + | 12 | Exosome | 6 months |
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Langi, G.; Szczerbinski, L.; Kretowski, A. Meta-Analysis of Differential miRNA Expression after Bariatric Surgery. J. Clin. Med. 2019, 8, 1220. https://doi.org/10.3390/jcm8081220
Langi G, Szczerbinski L, Kretowski A. Meta-Analysis of Differential miRNA Expression after Bariatric Surgery. Journal of Clinical Medicine. 2019; 8(8):1220. https://doi.org/10.3390/jcm8081220
Chicago/Turabian StyleLangi, Gladys, Lukasz Szczerbinski, and Adam Kretowski. 2019. "Meta-Analysis of Differential miRNA Expression after Bariatric Surgery" Journal of Clinical Medicine 8, no. 8: 1220. https://doi.org/10.3390/jcm8081220