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Open AccessArticle

Effect of F-18 Fluorodeoxyglucose Uptake by Bone Marrow on the Prognosis of Head and Neck Squamous Cell Carcinoma

1
Department of Nuclear Medicine, Catholic Kwandong University College of Medicine, International St. Mary’s Hospital, Incheon 22711, Korea
2
Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea
3
Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1169; https://doi.org/10.3390/jcm8081169
Received: 28 June 2019 / Revised: 22 July 2019 / Accepted: 1 August 2019 / Published: 4 August 2019
(This article belongs to the Special Issue Advances in Nuclear Medicine Imaging and Therapy)
The purpose of this study was to assess the relationship between F-18 fluorodeoxyglucose (FDG) uptake in bone marrow (BM) on positron emission tomography/computed tomography (PET/CT) and survival in patients with head and neck squamous cell carcinoma (HNSCC). We retrospectively enrolled 157 HNSCC patients who underwent staging FDG PET/CT and subsequent treatment. On PET/CT, primary tumor metabolic characteristics, mean FDG uptake of BM (BM SUV), and BM-to-liver uptake ratio (BLR) were measured. The prognostic significance of FDG uptake of BM for predicting disease progression-free survival and distant failure-free survival was assessed using a Cox proportional hazards regression model. In univariate analysis for disease progression-free survival, increased BM SUV and BLR were associated with poor survival. In multivariate analysis, BLR (p = 0.044; hazard ratio, 1.96), TNM stage (p = 0.014; hazard ratio, 2.87) and maximum FDG uptake of the primary tumor (p = 0.046; hazard ratio, 2.38) were independently associated with disease progression-free survival. For distant failure-free survival, BLR, TNM stage, tumor size, and metabolic parameters of the primary tumor showed prognostic significance in univariate analysis. However, none of the variables showed significance in multivariate analysis. FDG uptake of BM in HNSCC patients might be a significant predictor for disease progression-free survival. Further studies with large patient population are needed to validate the results. View Full-Text
Keywords: head and neck cancer; fluorodeoxyglucose F-18; positron emission tomography; bone marrow; prognosis head and neck cancer; fluorodeoxyglucose F-18; positron emission tomography; bone marrow; prognosis
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MDPI and ACS Style

Lee, J.W.; Ban, M.J.; Park, J.H.; Lee, S.M. Effect of F-18 Fluorodeoxyglucose Uptake by Bone Marrow on the Prognosis of Head and Neck Squamous Cell Carcinoma. J. Clin. Med. 2019, 8, 1169. https://doi.org/10.3390/jcm8081169

AMA Style

Lee JW, Ban MJ, Park JH, Lee SM. Effect of F-18 Fluorodeoxyglucose Uptake by Bone Marrow on the Prognosis of Head and Neck Squamous Cell Carcinoma. Journal of Clinical Medicine. 2019; 8(8):1169. https://doi.org/10.3390/jcm8081169

Chicago/Turabian Style

Lee, Jeong W.; Ban, Myung J.; Park, Jae H.; Lee, Sang M. 2019. "Effect of F-18 Fluorodeoxyglucose Uptake by Bone Marrow on the Prognosis of Head and Neck Squamous Cell Carcinoma" J. Clin. Med. 8, no. 8: 1169. https://doi.org/10.3390/jcm8081169

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