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Open AccessReview

Shock Index Predicts Outcome in Patients with Suspected Sepsis or Community-Acquired Pneumonia: A Systematic Review

1
Institute of Applied Health Sciences, University of Aberdeen, Scotland AB25 2ZD, UK
2
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1144; https://doi.org/10.3390/jcm8081144
Received: 10 July 2019 / Revised: 25 July 2019 / Accepted: 29 July 2019 / Published: 31 July 2019
(This article belongs to the Section Pulmonology)
Background: To improve outcomes for patients who present to hospital with suspected sepsis, it is necessary to accurately identify those at high risk of adverse outcomes as early and swiftly as possible. To assess the prognostic accuracy of shock index (heart rate divided by systolic blood pressure) and its modifications in patients with sepsis or community-acquired pneumonia. Methods: An electronic search of MEDLINE, EMBASE, Allie and Complementary Medicine Database (AMED), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Open Grey, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform (WHO ITRP) was conducted from conception to 26th March 2019. Eligible studies were required to assess the prognostic accuracy of shock index or its modifications for outcomes of death or requirement for organ support either in sepsis or pneumonia. The methodological appraisal was carried out using the Downs and Black checklist. Evidence was synthesised using a narrative approach due to heterogeneity. Results: Of 759 records screened, 15 studies (8697 patients) were included in this review. Shock index ≥ 1 at time of hospital presentation was a moderately accurate predictor of mortality in patients with sepsis or community-acquired pneumonia, with high specificity and low sensitivity. Only one study reported outcomes related to organ support. Conclusions: Elevated shock index at time of hospital presentation predicts mortality in sepsis with high specificity. Shock index may offer benefits over existing sepsis scoring systems due to its simplicity. View Full-Text
Keywords: shock index; sepsis; pneumonia; prognosis shock index; sepsis; pneumonia; prognosis
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    Doi: 10.5281/zenodo.3297905
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    Description: Shock index predicts outcome in patients with suspected sepsis or community acquired pneumonia: a systematic review Online data supplement
MDPI and ACS Style

Middleton, D.J.; Smith, T.O.; Bedford, R.; Neilly, M.; Myint, P.K. Shock Index Predicts Outcome in Patients with Suspected Sepsis or Community-Acquired Pneumonia: A Systematic Review. J. Clin. Med. 2019, 8, 1144. https://doi.org/10.3390/jcm8081144

AMA Style

Middleton DJ, Smith TO, Bedford R, Neilly M, Myint PK. Shock Index Predicts Outcome in Patients with Suspected Sepsis or Community-Acquired Pneumonia: A Systematic Review. Journal of Clinical Medicine. 2019; 8(8):1144. https://doi.org/10.3390/jcm8081144

Chicago/Turabian Style

Middleton, David J.; Smith, Toby O.; Bedford, Rachel; Neilly, Mark; Myint, Phyo K. 2019. "Shock Index Predicts Outcome in Patients with Suspected Sepsis or Community-Acquired Pneumonia: A Systematic Review" J. Clin. Med. 8, no. 8: 1144. https://doi.org/10.3390/jcm8081144

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