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Acupuncture for Depression: A Systematic Review and Meta-Analysis

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia
Translational Health Research Institute, School of Medicine, Western Sydney University, Penrith, NSW 2751, Australia
School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, Beijing 100029, China
Department of Health Sciences, University of York, Heslington, York YO10 5DD, UK
Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
Campbelltown Hospital, South West Sydney Local Health District, Campbelltown, NSW 5074, Australia
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(8), 1140;
Received: 9 July 2019 / Revised: 22 July 2019 / Accepted: 27 July 2019 / Published: 31 July 2019
(This article belongs to the Section Psychiatry)
Background: Depression is commonly treated with anti-depressant medication and/or psychological interventions. Patients with depression are common users of complementary therapies, such as acupuncture, either as a replacement for, or adjunct to, their conventional treatments. This systematic review and meta-analysis examined the effectiveness of acupuncture in major depressive disorder. Methods: A search of English (Medline, PsychINFO, Google Scholar, and CINAL), Chinese (China National Knowledge Infrastructure Database (CNKI) and Wanfang Database), and Korean databases was undertaken from 1980 to November 2018 for clinical trials using manual, electro, or laser acupuncture. Results: Twenty-nine studies including 2268 participants were eligible and included in the meta-analysis. Twenty-two trials were undertaken in China and seven outside of China. Acupuncture showed clinically significant reductions in the severity of depression compared to usual care (Hedges (g) = 0.41, 95% confidence interval (CI) 0.18 to 0.63), sham acupuncture (g = 0.55, 95% CI 0.31 to 0.79), and as an adjunct to anti-depressant medication (g = 0.84, 95% CI 0.61 to 1.07). A significant correlation between an increase in the number of acupuncture treatments delivered and reduction in the severity of depression (p = 0.015) was found. Limitations: The majority of the included trials were at a high risk of bias for performance blinding. The applicability of findings in Chinese populations to other populations is unclear, due to the use of a higher treatment frequency and number of treatments in China. The majority of trials did not report any post-trial follow-up and safety reporting was poor. Conclusions: Acupuncture may be a suitable adjunct to usual care and standard anti-depressant medication. View Full-Text
Keywords: depression; acupuncture; dosage; frequency depression; acupuncture; dosage; frequency
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MDPI and ACS Style

Armour, M.; Smith, C.A.; Wang, L.-Q.; Naidoo, D.; Yang, G.-Y.; MacPherson, H.; Lee, M.S.; Hay, P. Acupuncture for Depression: A Systematic Review and Meta-Analysis. J. Clin. Med. 2019, 8, 1140.

AMA Style

Armour M, Smith CA, Wang L-Q, Naidoo D, Yang G-Y, MacPherson H, Lee MS, Hay P. Acupuncture for Depression: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2019; 8(8):1140.

Chicago/Turabian Style

Armour, Mike, Caroline A. Smith, Li-Qiong Wang, Dhevaksha Naidoo, Guo-Yan Yang, Hugh MacPherson, Myeong S. Lee, and Phillipa Hay. 2019. "Acupuncture for Depression: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 8, no. 8: 1140.

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