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Fibromyalgia-Like Syndrome Associated with Parkinson’s Disease—A Cohort Study

1,2,†, 2,3,†, 2,3 and 2,3,*
1
Clinical Research Center, Soroka University Medical Center, Beer Sheva, Israel
2
Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel
3
Department of Neurology, Soroka University Medical Center, Beer Sheva, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to the manuscript.
J. Clin. Med. 2019, 8(8), 1118; https://doi.org/10.3390/jcm8081118
Received: 4 July 2019 / Revised: 22 July 2019 / Accepted: 23 July 2019 / Published: 28 July 2019
(This article belongs to the Section Neuroscience)
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Abstract

Parkinson’s disease (PD) and fibromyalgia (FM) are two relatively common disorders that are considered distinct diagnoses. The aim of this study was to investigate the epidemiological characteristics of patients with both PD and FM, as well as their comorbidities and medication use. We performed a population-based retrospective cohort study in Israel from 2000 to 2015. We identified patients with PD according to a refined medication tracer algorithm and patients with FM according to their medical records. Using the algorithm, we identified 2606 patients diagnosed with PD, 60 of them (2.3%) were also diagnosed with FM. Most of the patients were females (88.3%) and the mean age of FM diagnosis was 63.95 ± 12.27 years. These patients had a higher prevalence of depression, anxiety, and dementia. Of the patients diagnosed with PD + FM, 46 (76.7%) were diagnosed with FM after the diagnosis of PD. Patients with PD + FM used analgesics of distinct kinds in higher rates, as well as more anti-PD medications. We suggest that patients with PD + FM represent a distinct subgroup with a fibromyalgia-like syndrome associated with Parkinson’s disease (FLISPAD). Their PD is more treatment resistant, and they take more medications, both analgesics and anti-PD. View Full-Text
Keywords: Parkinson’s disease; central pain; cohort studies; fibromyalgia; epidemiology Parkinson’s disease; central pain; cohort studies; fibromyalgia; epidemiology
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Abuhasira, R.; Zlotnik, Y.; Horev, A.; Ifergane, G. Fibromyalgia-Like Syndrome Associated with Parkinson’s Disease—A Cohort Study. J. Clin. Med. 2019, 8, 1118.

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