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Open AccessArticle

Longtime Neurologic Outcome of Extracorporeal Membrane Oxygenation and Non Extracorporeal Membrane Oxygenation Acute Respiratory Distress Syndrome Survivors

1
Department of Anesthesiology, University Medical Center Goettingen, 37075 Goettingen, Germany
2
Interdisciplinary Department of Emergency Medicine, University Medical Center Goettingen, 37075 Goettingen, Germany
3
St. Josefs-Hospital Cloppenburg, Department of Anesthesia & Intensive Care, Krankenhausstr. 13, 49661 Cloppenburg, Germany
4
Hospital Stuttgart, Department of Neurology, Kriegsbergstr. 60, 70174 Stuttgart, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(7), 1020; https://doi.org/10.3390/jcm8071020
Received: 29 May 2019 / Revised: 7 July 2019 / Accepted: 9 July 2019 / Published: 12 July 2019
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Abstract

Neurologic complications following acute respiratory distress syndrome (ARDS) are well described, however, information on the neurologic outcome regarding peripheral nervous system complications in critically ill ARDS patients, especially those who received extracorporeal membrane oxygenation (ECMO) are lacking. In this prospective observational study 28 ARDS patients who survived after ECMO or conventional nonECMO treatment were examined for neurological findings. Nine patients had findings related to cranial nerve innervation, which differed between ECMO and nonECMO patients (p = 0.031). ECMO patients had severely increased patella tendon reflex (PTR) reflex levels (p = 0.027 vs. p = 0.125) as well as gastrocnemius tendon reflex (GTR) (p = 0.041 right, p = 0.149 left) were affected on the right, but not on the left side presumably associated with ECMO cannulation. Paresis (14.3% of patients) was only found in the ECMO group (p = 0.067). Paresthesia was frequent (nonECMO 53.8%, ECMO 62.5%; p = 0.064), in nonECMO most frequently due to initial trauma and polyneuropathy, in the ECMO group mainly due to impairments of N. cutaneus femoris lateralis (4 vs. 0; p = 0.031). Besides well-known central neurologic complications, more subtle complications were detected by thorough clinical examination. These findings are sufficient to hamper activities of daily living and impair quality of life and psychological health and are presumably directly related to ECMO therapy. View Full-Text
Keywords: extracorporeal circulation; ECMO; acute respiratory distress syndrome (ARDS) extracorporeal circulation; ECMO; acute respiratory distress syndrome (ARDS)
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Harnisch, L.-O.; Riech, S.; Mueller, M.; Gramueller, V.; Quintel, M.; Moerer, O. Longtime Neurologic Outcome of Extracorporeal Membrane Oxygenation and Non Extracorporeal Membrane Oxygenation Acute Respiratory Distress Syndrome Survivors. J. Clin. Med. 2019, 8, 1020.

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