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The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status

Laboratory of Preclinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy
Department of Biology, University of Naples Federico II, 80138 Naples, Italy
Section of Stem Cell and Development, Istituto di Ricerche Genetiche “Gaetano Salvatore” Biogem s.c. a.r.l., 83031 Ariano Irpino, Italy
Author to whom correspondence should be addressed.
Contributed equally as last authors.
J. Clin. Med. 2019, 8(5), 639; (registering DOI)
Received: 16 April 2019 / Revised: 4 May 2019 / Accepted: 6 May 2019 / Published: 9 May 2019
(This article belongs to the Section Molecular Medicine)
PDF [2056 KB, uploaded 19 May 2019]


Gastric cancer (GC) remains one of the major causes of cancer-related mortality worldwide. As for other types of cancers, several limitations to the success of current therapeutic GC treatments may be due to cancer drug resistance that leads to tumor recurrence and metastasis. Increasing evidence suggests that cancer stem cells (CSCs) are among the major causative factors of cancer treatment failure. The research of molecular CSC mechanisms and the regulation of their properties have been intensively studied. To date, molecular gastric cancer stem cell (GCSC) characterization remains largely incomplete. Among the GCSC-targeting approaches to overcome tumor progression, recent studies have focused their attention on microRNA (miRNA). The miRNAs are short non-coding RNAs which play an important role in the regulation of numerous cellular processes through the modulation of their target gene expression. In this review, we summarize and discuss recent findings on the role of miRNAs in GCSC regulation. In addition, we perform a meta-analysis aimed to identify novel miRNAs involved in GCSC homeostasis. View Full-Text
Keywords: gastric cancer; gastric cancer stem cells; self-renewal; miRNAs; meta-analysis gastric cancer; gastric cancer stem cells; self-renewal; miRNAs; meta-analysis

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Ruggieri, V.; Russi, S.; Zoppoli, P.; La Rocca, F.; Angrisano, T.; Falco, G.; Calice, G.; Laurino, S. The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status. J. Clin. Med. 2019, 8, 639.

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