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Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial

1
Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
2
Department of Orthopedics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 553; https://doi.org/10.3390/jcm8040553
Received: 24 March 2019 / Revised: 17 April 2019 / Accepted: 18 April 2019 / Published: 24 April 2019
(This article belongs to the Section Anesthesiology)
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Abstract

Arthroscopic rotator cuff repair causes acute postoperative hyperalgesia. Multimodal analgesia is preferable to opioid-based intravenous patient-controlled analgesia (IV-PCA) due to postoperative nausea and vomiting (PONV). We evaluated the effect of nefopam as a postoperative non-opioid analgesic after shoulder surgeries. A total of 180 adult patients were enrolled for arthroscopic rotator cuff repair. They were randomly assigned to nefopam (N) or control (C) groups and each group was reclassified according to the interscalene block (B) into NB, CB and NX, CX. Nefopam was applied at a constant dose intravenously during recovery. Pain scores were measured with a Visual Analogue Scale (VAS) before (T0), immediately after (T1), 30 min (T2) and 12 h (T3), 24 h (T4) and 48 h (T5) after surgery. There was no significant difference in demographic data. The overall VAS scores did not differ with regard to nefopam use, except for the NB group at T4 in intention to treat (ITT) analysis (p < 0.05). PONV occurred more frequently in the N group than in the C group (p < 0.05). Neither individual nor all risk factors were associated with PONV occurrence (p > 0.10). In conclusion, nefopam alone did not show a definite decrease in postoperative pain. It instead increased PONV regardless of risk factors. View Full-Text
Keywords: rotator cuff; nefopam hydrochloride; interscalene block; postoperative pain; Visual Analog Scale (VAS); postoperative nausea and vomiting (PONV) rotator cuff; nefopam hydrochloride; interscalene block; postoperative pain; Visual Analog Scale (VAS); postoperative nausea and vomiting (PONV)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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MDPI and ACS Style

Koh, H.J.; Joo, J.; Kim, Y.-S.; Lee, Y.J.; Yoo, W.; Lee, M.S.; Park, H.J. Analgesic Effect of Low Dose Nefopam Hydrochloride after Arthroscopic Rotator Cuff Repair: A Randomized Controlled Trial. J. Clin. Med. 2019, 8, 553.

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