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Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application

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Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat 116, 08005 Barcelona, Spain
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Musculoskeletal Tissue Engineering Group, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig de la Vall d’Hebron 129-139, 08035 Barcelona, Spain
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Department of Medicine, Universitat Autònoma de Barcelona, Passeig de la Vall d’Hebron 129-139, 08035 Barcelona, Spain
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Department of Surgery, School of Medicine & Hospital Clinic de Barcelona, University of Barcelona, 08036 Barcelona, Spain
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Institute of Biomedical Research Sant Pau (IIB-Sant Pau), 08035 Barcelona, Spain
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Molecular Genetics and Control of Pluripotency Laboratory, Department of Biomedicine, Institute of Neuroscience, Faculty of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
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Victor Chang Cardiac Research Institute, Sydney, NSW 2145, Australia
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Harry Perkins Research Institute, Centre for Cell Therapy and Regenerative Medicine (CCTRM), School of Medicine and Pharmacology, University of Western Australia, Perth, WA 6009, Australia
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Department of Physiology, Anatomy and Genetics, Oxford University, Oxford OX3 7BN, UK
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Centro de Oftalmología Barraquer, Institut Universitari Barraquer, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain
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Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 476; https://doi.org/10.3390/jcm8040476
Received: 18 February 2019 / Revised: 31 March 2019 / Accepted: 3 April 2019 / Published: 8 April 2019
In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)—or similar cell type—bank guidelines for clinical aims. To do this, we adapt the pre-existing SOP for CB banking that can be complementary for iPSCs. Some aspects of iPSC manufacturing and the particular nature of these cells call for special attention, such as the potential multiple applications of the cells, proper explanation to the donor for consent of use, the genomic stability and the risk of genetic privacy disclosure. Some aspects of the iPSC SOP are solidly established by CB banking procedures, other procedures have good consensus in the scientific and medical community, while others still need to be further debated and settled. Given the international sharing vocation of iPSC banking, there is an urgent need by scientists, clinicians and regulators internationally to harmonize standards and allow future sample interchange between many iPSC bank initiatives that are springing up worldwide. View Full-Text
Keywords: SOP; cord blood bank; induced pluripotent stem cells; cell therapy; advanced therapies medicinal products; HLA haplobank SOP; cord blood bank; induced pluripotent stem cells; cell therapy; advanced therapies medicinal products; HLA haplobank
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MDPI and ACS Style

Alvarez-Palomo, B.; Vives, J.; Casaroli-Marano, R.P.; G. Gomez, S.; Rodriguez Gómez, L.; Edel, M.J.; Querol Giner, S. Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application. J. Clin. Med. 2019, 8, 476.

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