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Open AccessArticle

HIV and cART-Associated Dyslipidemia Among HIV-Infected Children

1
Department of Pediatrics, College of Medicine and Health Sciences, Hawassa University, Hawassa 1560, Ethiopia
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Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
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Departments of Dermatology and Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA
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Department of Pharmacology, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia
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Adama General Hospital and Medical College, Adama 84, Ethiopia
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School of Laboratory Medicine, College of Medicine and Health Sciences, Hawassa University, Hawassa 1560, Ethiopia
7
Management Sciences for Health, Addis Ababa 1250, Ethiopia
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CDT Africa, College of Health Sciences, Addis Ababa University, Addis Ababa 9086, Ethiopia
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 430; https://doi.org/10.3390/jcm8040430
Received: 18 February 2019 / Revised: 15 March 2019 / Accepted: 26 March 2019 / Published: 28 March 2019
(This article belongs to the Section Hematology)
Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities. View Full-Text
Keywords: dyslipidemias; children; HIV; cART dyslipidemias; children; HIV; cART
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Tadesse, B.T.; Foster, B.A.; Chala, A.; Chaka, T.E.; Bizuayehu, T.; Ayalew, F.; H/Meskel, G.; Tadesse, S.; Jerene, D.; Makonnen, E.; Aklillu, E. HIV and cART-Associated Dyslipidemia Among HIV-Infected Children. J. Clin. Med. 2019, 8, 430.

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