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Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes

Department of Endocrinology and Nutrition, University Hospital and Health Science Research Institute Germans Trias i Pujol, 08916 Badalona, Spain
Center for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 08907 Barcelona, Spain
Biomedical Research Institute of Lleida, 25198 Lleida, Spain
Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 25198 Lleida, Spain
Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Suñer, CIBEROBN, Hospital Clinic, 08036 Barcelona, Spain
Department of Medicine, Barcelona Autonomous University (UAB), 08916 Barcelona, Spain
Primary Health Care Center Raval Sud, Gerència d’Atenció Primaria, Institut Català de la Salut, 08001 Barcelona, Spain
Department of Medicine, University of Padova, 35128 Padova, Italy
Department of Endocrinology and Nutrition, University Hospital de la Santa Creu i Sant Pau & Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain
Authors to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(4), 424;
Received: 15 March 2019 / Accepted: 22 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Clinical Research on Diabetic Complications)
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The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques. View Full-Text
Keywords: type 1 diabetes; plaque characteristics; carotid plaque; echogenic plaque type 1 diabetes; plaque characteristics; carotid plaque; echogenic plaque

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Castelblanco, E.; Betriu, À.; Hernández, M.; Granado-Casas, M.; Ortega, E.; Soldevila, B.; Ramírez-Morros, A.; Franch-Nadal, J.; Puig-Domingo, M.; Fernández, E.; Avogaro, A.; Alonso, N.; Mauricio, D. Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes. J. Clin. Med. 2019, 8, 424.

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