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J. Clin. Med. 2019, 8(3), 363; https://doi.org/10.3390/jcm8030363

Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain

1
Department of Psychiatry and Psychotherapy III, Ulm University, 89075 Ulm, Germany
2
Department of Psychiatry, Otto von Guericke University, 39120 Magdeburg, Germany
3
Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39106 Magdeburg, Germany
4
German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany
5
Department of Psychiatry, Eberhard Karls University, 72074 Tuebingen, Germany
6
Leibniz Institute for Neurobiology, 39120 Magdeburg, Germany
*
Author to whom correspondence should be addressed.
Received: 8 February 2019 / Revised: 5 March 2019 / Accepted: 12 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Novel Research in Sexuality and Mental Health)
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Abstract

Human sexual behavior is mediated by a complex interplay of cerebral and spinal centers, as well as hormonal, peripheral, and autonomic functions. Neuroimaging studies identified central neural signatures of human sexual responses comprising neural emotional, motivational, autonomic, and cognitive components. However, empirical evidence regarding the neuromodulation of these neural signatures of human sexual responses was scarce for decades. Pharmacological functional magnetic resonance imaging (fMRI) provides a valuable tool to examine the interaction between neuromodulator systems and functional network anatomy relevant for human sexual behavior. In addition, this approach enables the examination of potential neural mechanisms regarding treatment-related sexual dysfunction under psychopharmacological agents. In this article, we introduce common neurobiological concepts regarding cerebral sexual responses based on neuroimaging findings and we discuss challenges and findings regarding investigating the neuromodulation of neural sexual stimulus processing. In particular, we summarize findings from our research program investigating how neural correlates of sexual stimulus processing are modulated by serotonergic, dopaminergic, and noradrenergic antidepressant medication in healthy males. View Full-Text
Keywords: erotic stimulus processing; serotonin; noradrenaline; dopamine; fMRI; healthy; human erotic stimulus processing; serotonin; noradrenaline; dopamine; fMRI; healthy; human
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Graf, H.; Malejko, K.; Metzger, C.D.; Walter, M.; Grön, G.; Abler, B. Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain. J. Clin. Med. 2019, 8, 363.

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