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Article

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

by
Lorenzo Cavagna
1,*,
Ernesto Trallero-Araguás
2,
Federica Meloni
3,
Ilaria Cavazzana
4,
Jorge Rojas-Serrano
5,
Eugen Feist
6,
Giovanni Zanframundo
1,
Valentina Morandi
1,
Alain Meyer
7,8,
Jose Antonio Pereira da Silva
9,
Carlo Jorge Matos Costa
9,
Oyvind Molberg
10,
Helena Andersson
10,
Veronica Codullo
11,
Marta Mosca
12,
Simone Barsotti
12,
Rossella Neri
12,
Carlo Scirè
13,
Marcello Govoni
13,
Federica Furini
13,
Francisco Javier Lopez-Longo
14,
Julia Martinez-Barrio
14,
Udo Schneider
6,
Hanns-Martin Lorenz
15,
Andrea Doria
16,
Anna Ghirardello
16,
Norberto Ortego-Centeno
17,
Marco Confalonieri
18,
Paola Tomietto
19,
Nicolò Pipitone
20,
Ana Belen Rodriguez Cambron
21,
María Ángeles Blázquez Cañamero
21,
Reinhard Edmund Voll
22,
Sarah Wendel
22,
Salvatore Scarpato
23,
Francois Maurier
24,
Massimiliano Limonta
25,
Paolo Colombelli
26,
Margherita Giannini
8,
Bernard Geny
8,
Eugenio Arrigoni
27,
Elena Bravi
27,
Paola Migliorini
28,
Alessandro Mathieu
29,
Matteo Piga
29,
Ulrich Drott
30,
Christiane Delbrueck
30,
Jutta Bauhammer
31,
Giovanni Cagnotto
32,
Carlo Vancheri
33,
Gianluca Sambataro
33,
Ellen De Langhe
34,
Pier Paolo Sainaghi
35,
Cristina Monti
36,
Francesca Gigli Berzolari
36,
Mariaeva Romano
37,
Francesco Bonella
38,
Christof Specker
39,
Andreas Schwarting
40,
Ignacio Villa Blanco
41,
Carlo Selmi
42,
Angela Ceribelli
42,
Laura Nuno
43,
Antonio Mera-Varela
44,
Nair Perez Gomez
44,
Enrico Fusaro
45,
Simone Parisi
45,
Luigi Sinigaglia
46,
Nicoletta Del Papa
46,
Maurizio Benucci
47,
Marco Amedeo Cimmino
48,
Valeria Riccieri
49,
Fabrizio Conti
49,
Gian Domenico Sebastiani
50,
Annamaria Iuliano
50,
Giacomo Emmi
51,
Daniele Cammelli
52,
Marco Sebastiani
53,
Andreina Manfredi
53,
Javier Bachiller-Corral
54,
Walter Alberto Sifuentes Giraldo
54,
Giuseppe Paolazzi
55,
Lesley Ann Saketkoo
56,
Roberto Giorgi
57,
Fausto Salaffi
58,
Jose Cifrian
59,
Roberto Caporali
60,
Francesco Locatelli
1,
Enrico Marchioni
61,
Alberto Pesci
62,
Giulia Dei
62,
Maria Rosa Pozzi
62,
Lomater Claudia
63,
Jorg Distler
64,
Johannes Knitza
64,
George Schett
64,
Florenzo Iannone
65,
Marco Fornaro
65,
Franco Franceschini
4,
Luca Quartuccio
66,
Roberto Gerli
67,
Elena Bartoloni
67,
Silvia Bellando Randone
68,
Giuseppe Zampogna
69,
Montserrat I. Gonzalez Perez
5,
Mayra Mejia
5,
Esther Vicente
70,
Konstantinos Triantafyllias
71,
Raquel Lopez-Mejias
72,
Marco Matucci-Cerinic
68,
Albert Selva-O’Callaghan
2,
Santos Castañeda
70,73,
Carlomaurizio Montecucco
1 and
Miguel Angel Gonzalez-Gay
72add Show full author list remove Hide full author list
1
Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
2
Department of Internal Medicine, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, Spain
3
Department of Pneumology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN Lung, 27100 Pavia, Italy
4
Department of Rheumatology, University and ASST Spedali Civili—Brescia and ERN ReCONNET, 25123 Brescia, Italy
5
Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico
6
Department of Rheumatology, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
7
Department of Rheumatology, Hôpitaux Universitaires de Strasbourg and ERN ReCONNET, 67000 Strasbourg, France
8
Service de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, France
9
Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
10
Department of Rheumatology, Oslo University Hospital, 0372 Oslo, Norway
11
Department of Rheumatology, Cochin Hospital, 75014 Paris, France
12
Department of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
13
Department of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy
14
Department of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
15
Department of Rheumatology, University of Heidelberg, 69117 Heidelberg, Germany
16
Department of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, Italy
17
Department of Rheumatology, Hospital Universitario San Cecilio, 18016 Granada, Spain
18
Department of Pneumology, University Hospital of Cattinara, 34149 Trieste, Italy
19
Department of Rheumatology, University Hospital of Cattinara, 34149 Trieste, Italy
20
Department of Rheumatology, S. Maria Hospital—IRCCS, 42123 Reggio Emilia, Italy
21
Department of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, Spain
22
Department of Rheumatology and Clinical Immunology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany
23
Department of Rheumatology, Ospedale “ Scarlato” Scafati, 84018 Scafati, Italy
24
Department of Rheumatology, HP Metz, Hopital Belle-Ile, 57000 Metz, France
25
Department of Rheumatology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy
26
Department of Rheumatology, Ospedale di Treviglio, 24047 Treviglio, Italy
27
Department of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy
28
Department of Immunology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
29
Department of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, Italy
30
Department of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany
31
Department of Rheumatology, ACURA Centre for Rheumatic Diseases, 76530 Baden-Baden, Germany
32
Department of Rheumatology, Skane University Hospital, 22242 Lund, Sweden
33
Department of Pneumology, AOU Catania, 95100 Catania, Italy
34
Department of Rheumatology, University Hospitals, 3000 Leuven, Belgium
35
Department of Rheumatology at CAAD, DiMet, University of Eastern Piedmont (UPO) and AOU “Maggiore della Carità”, 28100 Novara, Italy
36
Department of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, Italy
37
Department of Rheumatology, Niguarda Hospital, 20162 Milan, Italy
38
Department of Pneumology, Ruhrlandklinik, University of Duisburg-Essen and ERN Lung, 45239 Essen, Germany
39
Department of Rheumatology, Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany
40
Department of Rheumatology, Johannes Gutenberg-University, 55122 Mainz, Germany
41
Department of Rheumatology, Sierrallana Hospital, 39300 Torrelavega, Spain
42
Department of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
43
Department of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, Spain
44
Department of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, Spain
45
Department of Rheumatology, Città della Salute e della Scienza, 10126 Turin, Italy
46
Department of Rheumatology, Hospital G. Pini—CTO, 20122 Milan, Italy
47
Department of Rheumatology, Azienda Ospedaliera San Giovanni di Dio, 50143 Firenze, Italy
48
Department of Rheumatology, University of Genova 16126 Genova, Italy
49
Department of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, Italy
50
Department of Rheumatology, Ospedale San Camillo, 00152 Rome, Italy
51
Department of Internal Medicine, AOU Careggi, 50134 Firenze, Italy
52
Department of Immunology, AOU Careggi, 50134 Firenze, Italy
53
Department of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy
54
Department of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
55
Department of Rheumatology, Ospedale Santa Chiara, 38122 Trento, Italy
56
University Medical Center- Comprehensive Pulmonary Hypertension Center & Interstitial Lung Disease Clinic Programs, Louisiana State University and Tulane University Schools of Medicine, Pulmonary Division New Orleans, New Orleans, LA 1542, USA
57
Department of Rheumatology, ASL Cuneo 2, 12051 Alba, Italy
58
Department of Rheumatology, Polytechnic University of Marche, C. Urbani Hospital, 60035 Jesi, Italy
59
Department of Pneumology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain
60
Department of Clinical Sciences and Community Health, University of Milan and Gaetano Pini Hospital, 20122 Milan, Italy
61
Department of Neurology, IRCCS Mondino Foundation, 27100 Pavia, Italy
62
Department of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy
63
Department of Rheumatology, Mauriziano Hospital, 10126 Turin, Italy
64
Department of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
65
Rheumatology Unit—DETO, University of Bari, 70121 Bari, Italy
66
Clinic of Rheumatology, Department of Medicine, Santa Maria della Misericordia Hospital and University of Udine, 33100 Udine, Italy
67
Rheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, Italy
68
Department of Rheumatology, AOU Careggi, 50134 Firenze, Italy
69
Department of Rheumatology, AO Brunico, 39031 Bruneck, Italy
70
Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, Spain
71
Department of Rheumatology, ACURA Center for Rheumatic Diseases, 55543 Bad Kreuznach, Germany
72
Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain
73
Catedra UAM-Roche, EPID Future, Universitad Autonoma de Madrid, 28006 Madrid, Spain
 
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*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(11), 2013; https://doi.org/10.3390/jcm8112013
Received: 13 August 2019 / Revised: 12 September 2019 / Accepted: 12 November 2019 / Published: 18 November 2019
(This article belongs to the Section Molecular Diagnostics)
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Abstract

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition. View Full-Text
Keywords: antisynthetase syndrome; antisynthetase antibodies; arthritis; myositis; interstitial lung disease antisynthetase syndrome; antisynthetase antibodies; arthritis; myositis; interstitial lung disease
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MDPI and ACS Style

Cavagna, L.; Trallero-Araguás, E.; Meloni, F.; Cavazzana, I.; Rojas-Serrano, J.; Feist, E.; Zanframundo, G.; Morandi, V.; Meyer, A.; Pereira da Silva, J.A.; Matos Costa, C.J.; Molberg, O.; Andersson, H.; Codullo, V.; Mosca, M.; Barsotti, S.; Neri, R.; Scirè, C.; Govoni, M.; Furini, F.; Lopez-Longo, F.J.; Martinez-Barrio, J.; Schneider, U.; Lorenz, H.-M.; Doria, A.; Ghirardello, A.; Ortego-Centeno, N.; Confalonieri, M.; Tomietto, P.; Pipitone, N.; Rodriguez Cambron, A.B.; Blázquez Cañamero, M.Á.; Voll, R.E.; Wendel, S.; Scarpato, S.; Maurier, F.; Limonta, M.; Colombelli, P.; Giannini, M.; Geny, B.; Arrigoni, E.; Bravi, E.; Migliorini, P.; Mathieu, A.; Piga, M.; Drott, U.; Delbrueck, C.; Bauhammer, J.; Cagnotto, G.; Vancheri, C.; Sambataro, G.; De Langhe, E.; Sainaghi, P.P.; Monti, C.; Gigli Berzolari, F.; Romano, M.; Bonella, F.; Specker, C.; Schwarting, A.; Villa Blanco, I.; Selmi, C.; Ceribelli, A.; Nuno, L.; Mera-Varela, A.; Perez Gomez, N.; Fusaro, E.; Parisi, S.; Sinigaglia, L.; Del Papa, N.; Benucci, M.; Cimmino, M.A.; Riccieri, V.; Conti, F.; Sebastiani, G.D.; Iuliano, A.; Emmi, G.; Cammelli, D.; Sebastiani, M.; Manfredi, A.; Bachiller-Corral, J.; Sifuentes Giraldo, W.A.; Paolazzi, G.; Saketkoo, L.A.; Giorgi, R.; Salaffi, F.; Cifrian, J.; Caporali, R.; Locatelli, F.; Marchioni, E.; Pesci, A.; Dei, G.; Pozzi, M.R.; Claudia, L.; Distler, J.; Knitza, J.; Schett, G.; Iannone, F.; Fornaro, M.; Franceschini, F.; Quartuccio, L.; Gerli, R.; Bartoloni, E.; Bellando Randone, S.; Zampogna, G.; Gonzalez Perez, M.I.; Mejia, M.; Vicente, E.; Triantafyllias, K.; Lopez-Mejias, R.; Matucci-Cerinic, M.; Selva-O’Callaghan, A.; Castañeda, S.; Montecucco, C.; Gonzalez-Gay, M.A. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course. J. Clin. Med. 2019, 8, 2013. https://doi.org/10.3390/jcm8112013

AMA Style

Cavagna L, Trallero-Araguás E, Meloni F, Cavazzana I, Rojas-Serrano J, Feist E, Zanframundo G, Morandi V, Meyer A, Pereira da Silva JA, Matos Costa CJ, Molberg O, Andersson H, Codullo V, Mosca M, Barsotti S, Neri R, Scirè C, Govoni M, Furini F, Lopez-Longo FJ, Martinez-Barrio J, Schneider U, Lorenz H-M, Doria A, Ghirardello A, Ortego-Centeno N, Confalonieri M, Tomietto P, Pipitone N, Rodriguez Cambron AB, Blázquez Cañamero MÁ, Voll RE, Wendel S, Scarpato S, Maurier F, Limonta M, Colombelli P, Giannini M, Geny B, Arrigoni E, Bravi E, Migliorini P, Mathieu A, Piga M, Drott U, Delbrueck C, Bauhammer J, Cagnotto G, Vancheri C, Sambataro G, De Langhe E, Sainaghi PP, Monti C, Gigli Berzolari F, Romano M, Bonella F, Specker C, Schwarting A, Villa Blanco I, Selmi C, Ceribelli A, Nuno L, Mera-Varela A, Perez Gomez N, Fusaro E, Parisi S, Sinigaglia L, Del Papa N, Benucci M, Cimmino MA, Riccieri V, Conti F, Sebastiani GD, Iuliano A, Emmi G, Cammelli D, Sebastiani M, Manfredi A, Bachiller-Corral J, Sifuentes Giraldo WA, Paolazzi G, Saketkoo LA, Giorgi R, Salaffi F, Cifrian J, Caporali R, Locatelli F, Marchioni E, Pesci A, Dei G, Pozzi MR, Claudia L, Distler J, Knitza J, Schett G, Iannone F, Fornaro M, Franceschini F, Quartuccio L, Gerli R, Bartoloni E, Bellando Randone S, Zampogna G, Gonzalez Perez MI, Mejia M, Vicente E, Triantafyllias K, Lopez-Mejias R, Matucci-Cerinic M, Selva-O’Callaghan A, Castañeda S, Montecucco C, Gonzalez-Gay MA. Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course. Journal of Clinical Medicine. 2019; 8(11):2013. https://doi.org/10.3390/jcm8112013

Chicago/Turabian Style

Cavagna, Lorenzo, Ernesto Trallero-Araguás, Federica Meloni, Ilaria Cavazzana, Jorge Rojas-Serrano, Eugen Feist, Giovanni Zanframundo, Valentina Morandi, Alain Meyer, Jose A. Pereira da Silva, Carlo J. Matos Costa, Oyvind Molberg, Helena Andersson, Veronica Codullo, Marta Mosca, Simone Barsotti, Rossella Neri, Carlo Scirè, Marcello Govoni, Federica Furini, Francisco J. Lopez-Longo, Julia Martinez-Barrio, Udo Schneider, Hanns-Martin Lorenz, Andrea Doria, Anna Ghirardello, Norberto Ortego-Centeno, Marco Confalonieri, Paola Tomietto, Nicolò Pipitone, Ana B. Rodriguez Cambron, María Á. Blázquez Cañamero, Reinhard E. Voll, Sarah Wendel, Salvatore Scarpato, Francois Maurier, Massimiliano Limonta, Paolo Colombelli, Margherita Giannini, Bernard Geny, Eugenio Arrigoni, Elena Bravi, Paola Migliorini, Alessandro Mathieu, Matteo Piga, Ulrich Drott, Christiane Delbrueck, Jutta Bauhammer, Giovanni Cagnotto, Carlo Vancheri, Gianluca Sambataro, Ellen De Langhe, Pier P. Sainaghi, Cristina Monti, Francesca Gigli Berzolari, Mariaeva Romano, Francesco Bonella, Christof Specker, Andreas Schwarting, Ignacio Villa Blanco, Carlo Selmi, Angela Ceribelli, Laura Nuno, Antonio Mera-Varela, Nair Perez Gomez, Enrico Fusaro, Simone Parisi, Luigi Sinigaglia, Nicoletta Del Papa, Maurizio Benucci, Marco A. Cimmino, Valeria Riccieri, Fabrizio Conti, Gian D. Sebastiani, Annamaria Iuliano, Giacomo Emmi, Daniele Cammelli, Marco Sebastiani, Andreina Manfredi, Javier Bachiller-Corral, Walter A. Sifuentes Giraldo, Giuseppe Paolazzi, Lesley A. Saketkoo, Roberto Giorgi, Fausto Salaffi, Jose Cifrian, Roberto Caporali, Francesco Locatelli, Enrico Marchioni, Alberto Pesci, Giulia Dei, Maria R. Pozzi, Lomater Claudia, Jorg Distler, Johannes Knitza, George Schett, Florenzo Iannone, Marco Fornaro, Franco Franceschini, Luca Quartuccio, Roberto Gerli, Elena Bartoloni, Silvia Bellando Randone, Giuseppe Zampogna, Montserrat I. Gonzalez Perez, Mayra Mejia, Esther Vicente, Konstantinos Triantafyllias, Raquel Lopez-Mejias, Marco Matucci-Cerinic, Albert Selva-O’Callaghan, Santos Castañeda, Carlomaurizio Montecucco, and Miguel A. Gonzalez-Gay. 2019. "Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course" Journal of Clinical Medicine 8, no. 11: 2013. https://doi.org/10.3390/jcm8112013

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