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Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine–Glutamate Co-release as Future Target in Substance Use Disorder

Department of Organismal Biology, Uppsala University, S-752 36 Uppsala, Sweden
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J. Clin. Med. 2019, 8(11), 1887; https://doi.org/10.3390/jcm8111887
Received: 9 October 2019 / Revised: 29 October 2019 / Accepted: 1 November 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Assessment & Treatment of Addictions: New Tools for Old Problems)
Dopamine–glutamate co-release is a unique property of midbrain neurons primarily located in the ventral tegmental area (VTA). Dopamine neurons of the VTA are important for behavioral regulation in response to rewarding substances, including natural rewards and addictive drugs. The impact of glutamate co-release on behaviors regulated by VTA dopamine neurons has been challenging to probe due to lack of selective methodology. However, several studies implementing conditional knockout and optogenetics technologies in transgenic mice have during the past decade pointed towards a role for glutamate co-release in multiple physiological and behavioral processes of importance to substance use and abuse. In this review, we discuss these studies to highlight findings that may be critical when considering mechanisms of importance for prevention and treatment of substance abuse. View Full-Text
Keywords: addiction; reward; transgenic mice; optogenetics; self-administration; cocaine; amphetamine addiction; reward; transgenic mice; optogenetics; self-administration; cocaine; amphetamine
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Bimpisidis, Z.; Wallén-Mackenzie, Å. Neurocircuitry of Reward and Addiction: Potential Impact of Dopamine–Glutamate Co-release as Future Target in Substance Use Disorder. J. Clin. Med. 2019, 8, 1887.

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