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Open AccessArticle

Validation of Identified Susceptible Gene Variants for New-Onset Diabetes in Renal Transplant Recipients

1
Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 130-702, Korea
2
Division of Healthcare Innovation, TheragenEtex Bio Institute Co., Ltd., Suwon 443-721, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1696; https://doi.org/10.3390/jcm8101696
Received: 9 September 2019 / Revised: 3 October 2019 / Accepted: 12 October 2019 / Published: 16 October 2019
(This article belongs to the Special Issue Recent Advances and Clinical Outcomes of Kidney Transplantation)
Genome-wide association studies (GWAS) and candidate gene approaches have identified single nucleotide polymorphisms (SNPs) associated with new-onset diabetes after renal transplantation (NODAT). We evaluated associations between NODAT and SNPs identified in previous studies. We genotyped 1102 renal transplant recipients from the Korean Organ Transplantation Registry (KOTRY) database; 13 SNPs were assessed for associations with NODAT (occurring in 254 patients; 23.0%), within one year after transplantation. The frequency of the T allele at KCNQ1 rs2237892 was significantly lower in patients with NODAT compared to control patients (0.30 vs. 0.39; p = 8.5 × 10−5). The T allele at rs2237892 was significantly associated with decreased risk of NODAT after adjusting for multiple variables, compared to the C allele (OR 0.63, 95% CI 0.51–0.79; p = 5.5 × 10−5). Dominant inheritance modeling showed that CT/TT genotypes were associated with a lower risk for development of NODAT (OR 0.56, 95% CI 0.42–0.76; p = 2.0 × 10−4) compared to the CC genotype. No other SNPs were associated with NODAT. Our study validated the protective effect of T allele at KCNQ1 rs2237892 on the development of NODAT in a large cohort of renal transplant recipients. Our findings on susceptibility variants might be a useful tool to predict NODAT development after renal transplantation. View Full-Text
Keywords: new onset diabetes after renal transplantation; single nucleotide polymorphisms; renal transplantation new onset diabetes after renal transplantation; single nucleotide polymorphisms; renal transplantation
MDPI and ACS Style

Hwang, H.S.; Hong, K.-W.; Kim, J.S.; Kim, Y.G.; Moon, J.Y.; Jeong, K.H.; Lee, S.H.; The Korean Organ Transplantation Registry Study Group. Validation of Identified Susceptible Gene Variants for New-Onset Diabetes in Renal Transplant Recipients. J. Clin. Med. 2019, 8, 1696.

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