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Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk

Division of Surgery, School of Medicine, University of Crete, Heraklion, 71500 Crete, Greece
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, 68100 Alexandroupolis, Greece
IBD Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA 10833, USA
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1669;
Received: 1 October 2019 / Revised: 8 October 2019 / Accepted: 11 October 2019 / Published: 12 October 2019
(This article belongs to the Section Oncology)
Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to be implicated in the regulation of chronic inflammation, one of the predisposing factors for oncogenesis and disease progression. However, an interrelationship between stress, inflammation, and malignancy, at least at the molecular level, still remains unclear. Here, we attempt to summarize the current knowledge that supports the inseparable link between chronic stress, inflammation, and colorectal cancer (CRC), by modulation of a cascade of molecular signaling pathways, which are under the regulation of CRH-family members expressed in the brain and periphery. The understanding of the molecular basis of the link among these processes may provide a step forward towards personalized medicine in terms of CRC diagnosis, prognosis and therapeutic targeting. View Full-Text
Keywords: colorectal cancer (CRC); inflammation; stress; corticotropin releasing hormone (CRH) colorectal cancer (CRC); inflammation; stress; corticotropin releasing hormone (CRH)
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Baritaki, S.; de Bree, E.; Chatzaki, E.; Pothoulakis, C. Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk. J. Clin. Med. 2019, 8, 1669.

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