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Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial

1
Research, Health and Podiatry Unit, Department of Health Sciences, Faculty of Nursing and Podiatry, Universidade da Coruña, 15403 Ferrol, Spain
2
Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
3
Faculty of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, Spain
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University Center of Plasencia, Universidad de Extremadura, 10600 Badajoz, Spain
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Department of Nursing, Faculty of Nursing and Podiatry, Universidad de Valencia, 46100 Valencia, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(10), 1552; https://doi.org/10.3390/jcm8101552
Received: 14 August 2019 / Revised: 16 September 2019 / Accepted: 24 September 2019 / Published: 27 September 2019
(This article belongs to the Section Hematology)
Background: Leukocyte and platelet-rich fibrin (L-PRF) may be considered a co-adjuvant intervention that may play a key role in blood coagulation and tissue repair after nail surgeries. The aim of this study was to determine the effectiveness of L-PRF versus nitrofurazone on the post-surgical bleeding and wound cicatrization period in patients with bilateral onychocryptosis during surgeries of chemical matrixectomies with 88% phenol solution. Methods: A randomized single-blind clinical trial was registered with the European Clinical Trials Database (EudraCT) with identification number 2016-002048-18. Twenty healthy participants with bilateral onychocryptosis (n = 40) were recruited and bilaterally received both protocols for both halluces. Patients with a mean age mean of 45.55 ± 12.19 years attended a specialized foot and ankle surgery clinic. Both halluces of each patient were randomized and allocated to receive L-PRF (experimental group; n = 20 halluces) or nitrofurazone (control group; n = 20 halluces) interventions in conjunction with surgery of chemical matrixectomies with 88% phenol solution for bilateral ingrown of toenail border (medial and lateral). Patients were blinded to their intervention in each hallux. The primary outcome measurement was post-surgical bleeding. The secondary outcome measurements were post-surgical pain intensity, inflammation, infection, analgesic intake, and wound cicatrization period. Results: Statistically significant differences (p < 0.001) were found between both groups showing a reduction for wound cicatrization period and post-surgical bleeding for the L-PRF intervention with respect to nitrofurazone treatment. The rest of the outcome measurements did not show any statistically significant differences (p > 0.05). Conclusions: L-PRF rather than nitrofurazone in conjunction with chemical matrixectomies performed with 88% phenol solution reduced the wound cicatrization period and bleeding after nail surgery. Thus, L-PRF may be considered a first-line co-adjuvant intervention for patients who suffer from nail problems, such as onychocryptosis, that require surgical procedures. View Full-Text
Keywords: inflammation; nail diseases; pain; platelet rich plasma; surgery inflammation; nail diseases; pain; platelet rich plasma; surgery
MDPI and ACS Style

Garrido-Castells, X.; Becerro-de-Bengoa-Vallejo, R.; Calvo-Lobo, C.; Losa-Iglesias, M.E.; Palomo-López, P.; Navarro-Flores, E.; López-López, D. Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial. J. Clin. Med. 2019, 8, 1552. https://doi.org/10.3390/jcm8101552

AMA Style

Garrido-Castells X, Becerro-de-Bengoa-Vallejo R, Calvo-Lobo C, Losa-Iglesias ME, Palomo-López P, Navarro-Flores E, López-López D. Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial. Journal of Clinical Medicine. 2019; 8(10):1552. https://doi.org/10.3390/jcm8101552

Chicago/Turabian Style

Garrido-Castells, Xavier, Ricardo Becerro-de-Bengoa-Vallejo, César Calvo-Lobo, Marta E. Losa-Iglesias, Patricia Palomo-López, Emmanuel Navarro-Flores, and Daniel López-López. 2019. "Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial" Journal of Clinical Medicine 8, no. 10: 1552. https://doi.org/10.3390/jcm8101552

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