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Case Report

Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

1
Centre for Human Reproduction, Genesis Athens Clinic, 14-16, Papanikoli, 15232 Athens, Greece
2
Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, Greece
3
Assisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
J. Clin. Med. 2019, 8(1), 1; https://doi.org/10.3390/jcm8010001
Received: 20 November 2018 / Revised: 12 December 2018 / Accepted: 14 December 2018 / Published: 20 December 2018
(This article belongs to the Section Obstetrics & Gynecology)
This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient’s follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation. View Full-Text
Keywords: premature menopause; autologous platelet rich plasma; pregnancy; rejuvenation; menstrual restoration premature menopause; autologous platelet rich plasma; pregnancy; rejuvenation; menstrual restoration
MDPI and ACS Style

Sfakianoudis, K.; Simopoulou, M.; Nitsos, N.; Rapani, A.; Pappas, A.; Pantou, A.; Chronopoulou, M.; Deligeoroglou, E.; Koutsilieris, M.; Pantos, K. Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause. J. Clin. Med. 2019, 8, 1. https://doi.org/10.3390/jcm8010001

AMA Style

Sfakianoudis K, Simopoulou M, Nitsos N, Rapani A, Pappas A, Pantou A, Chronopoulou M, Deligeoroglou E, Koutsilieris M, Pantos K. Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause. Journal of Clinical Medicine. 2019; 8(1):1. https://doi.org/10.3390/jcm8010001

Chicago/Turabian Style

Sfakianoudis, Konstantinos, Mara Simopoulou, Nikolaos Nitsos, Anna Rapani, Athanasios Pappas, Agni Pantou, Margarita Chronopoulou, Efthymios Deligeoroglou, Michael Koutsilieris, and Konstantinos Pantos. 2019. "Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause" Journal of Clinical Medicine 8, no. 1: 1. https://doi.org/10.3390/jcm8010001

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