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Clinicopathologic Features and Treatment Outcomes in Patients with Stage I, High-Risk Histology or High-Grade Endometrial Cancer after Primary Staging Surgery: A Taiwanese Gynecologic Oncology Group Study

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Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan
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Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua 500, Taiwan
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Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung 407, Taiwan
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Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, Tainan 704, Taiwan
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Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei 104, Taiwan
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Department of Obstetrics and Gynecology, Tri Service General Hospital, Taipei 114, Taiwan
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Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
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Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei 106, Taiwan
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Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
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Department of Obstetrics and Gynecology, ChiaYi Chang Gung Memorial Hospital, ChiaYi 613, Taiwan
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Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan
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Department of Obstetrics and Gynecology, Yuan’s General Hospital, Kaohsiung 802, Taiwan
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Department of Obstetrics and Gynecology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
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Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(9), 254; https://doi.org/10.3390/jcm7090254
Received: 9 August 2018 / Revised: 29 August 2018 / Accepted: 31 August 2018 / Published: 4 September 2018
(This article belongs to the Section Obstetrics & Gynecology)
To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the clinical and pathological factors in relation to prognosis. A total of 267 patients (stage IA; n = 175, stage IB; n = 92) were included. Among the clinicopathological features, stage and age were significant prognostic factors. The recurrence rate and overall survival for stage IB versus IA were 22.8% versus 9.1% (p = 0.003) and 149.7 months versus 201.8 months (p < 0.001), respectively. The patients >60 years of age also had a higher recurrence rate (21.7% versus 9.7%, p = 0.008) and poorer survival (102.0 months versus 196.8 months, p = 0.001) than those ≤60 years of age. Distant recurrence (64.9%) occurred more frequently than local recurrence (24.3%) and local combined with distant recurrence (10.8%) (p < 0.001). The postoperative treatment modality had no impact on tumor recurrence rate, recurrence site, or overall survival. Distant recurrence is a major cause of treatment failure in patients with stage I, high-risk endometrial cancer. However, current adjuvant treatment appeared to have little effect in preventing its occurrence. View Full-Text
Keywords: clinicopathologic features; outcomes; stage I; high-risk histology; high-grade; endometrial cancer clinicopathologic features; outcomes; stage I; high-risk histology; high-grade; endometrial cancer
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Yen, M.-S.; Chen, T.-H.; Ke, Y.-M.; Hsu, K.-F.; Chen, J.-R.; Yu, M.-H.; Fu, H.-C.; Huang, C.-Y.; Chiang, A.-J.; Chen, C.-Y.; Hsiao, S.-M.; Kan, Y.-Y.; Liu, F.-S. Clinicopathologic Features and Treatment Outcomes in Patients with Stage I, High-Risk Histology or High-Grade Endometrial Cancer after Primary Staging Surgery: A Taiwanese Gynecologic Oncology Group Study. J. Clin. Med. 2018, 7, 254.

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