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Open AccessArticle

Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia

by Yiying Zhang 1,2 and Hongbin Qiu 1,2,*
School of Public Health, Jiamusi University, Jiamusi 154007, China
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(8), 210;
Received: 16 July 2018 / Revised: 8 August 2018 / Accepted: 9 August 2018 / Published: 11 August 2018
(This article belongs to the Section Hematology)
To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females. View Full-Text
Keywords: hyperuricemia; folate; vitamin B6; vitamin B12; NHANES hyperuricemia; folate; vitamin B6; vitamin B12; NHANES
MDPI and ACS Style

Zhang, Y.; Qiu, H. Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia. J. Clin. Med. 2018, 7, 210.

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