Next Article in Journal
Use of Estimating Equations for Dosing Antimicrobials in Patients with Acute Kidney Injury Not Receiving Renal Replacement Therapy
Previous Article in Journal
Salivary Biomarkers of Oxidative Stress in Children with Chronic Kidney Disease
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
J. Clin. Med. 2018, 7(8), 210; https://doi.org/10.3390/jcm7080210

Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia

1,2
and
1,2,*
1
School of Public Health, Jiamusi University, Jiamusi 154007, China
2
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China
*
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 8 August 2018 / Accepted: 9 August 2018 / Published: 11 August 2018
Full-Text   |   PDF [234 KB, uploaded 11 August 2018]

Abstract

To assess the association between intake of folate, vitamin B6, and vitamin B12 with hyperuricemia (HU) among adults from the United States (US), we extracted relevant data from 24,975 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001–2014. All dietary intake was evaluated by 24-h dietary recalls. Multivariable logistic regression analysis was performed to explore the associations after adjustment for confounders. Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q5 of folate (dietary folate equivalent, DFE) intake were 0.84 (95% CI, 0.73–0.96), 0.84 (0.73–0.97), 0.72 (0.62–0.84), and 0.64 (0.53–0.77), respectively (p for trend <0.0001). In females, adjusted ORs in Q2 to Q4 of folate (DFE) intake were 0.84 (95% CI, 0.71–0.99), 0.81 (0.68–0.96), and 0.82 (0.68–0.99), with a p for trend of 0.1475. Our findings indicated the intakes of total folate, folic acid, food folate, folate (DFE), vitamin B12, but not vitamin B6, were inversely related to the risk of HU in males. A lower risk of HU with higher intakes of total folate, food folate, and folate (DFE) was found in females, but with no association between intakes of folic acid, vitamin B6, B12, and the risk of HU for females. View Full-Text
Keywords: hyperuricemia; folate; vitamin B6; vitamin B12; NHANES hyperuricemia; folate; vitamin B6; vitamin B12; NHANES
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Zhang, Y.; Qiu, H. Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia. J. Clin. Med. 2018, 7, 210.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top