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Evaluation of Dose Dependent Maternal Exposure to Bisphenol A on Thyroid Functions in Newborns

1
Pediatrics, Faculty of Medicine, Near East University, 99138 Nicosia, Cyprus
2
Department of Medical Biochemistry, Faculty of Medicine, Near East University, 99138 Nicosia, Cyprus
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(6), 119; https://doi.org/10.3390/jcm7060119
Received: 22 April 2018 / Revised: 15 May 2018 / Accepted: 21 May 2018 / Published: 23 May 2018
(This article belongs to the Section Pharmacology)
Bisphenol A (BPA) is an endocrine-disrupting chemical compound that is mainly used in industrial products as packaging and plastics. It usually transmits to humans via oral route from food-contact material. BPA has demonstrated to be found in body fluids with a higher amount of fetal tissues due to bio-accumulation. Although it has been reported to affect the endocrine system, results on thyroid functions of newborns are conflicting. The aim of the present study is to demonstrate the effect of different levels of BPA in cord blood on the thyroid functions of newborns, according to gender. Methods: The study population included 88 newborns. The BPA levels, Thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels of cord blood were measured. In addition, SPINA-GT (thyroid’ incretory capasity), TSH Index (TSHI), standardized TSHI (sTSHI) were calculated and demographic characteristics of participants were noted. Results: The mean of cord blood BPA was 4.934 ± 2.33 ng/mL. When evaluated according to quantiles of BPA, no association was found between BPA and thyroid hormone levels, as well as, SPINA-GT, TSHI, sTSHI in both genders. Conclusion: Although BPA has been shown to contaminate cord blood, no significant effect was detected on thyroid hormones, SPINA-GT, TSHI and sTSHI. Further investigations with larger study populations are warranted. View Full-Text
Keywords: Bishenol A; thyroid hormone; newborn Bishenol A; thyroid hormone; newborn
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Sanlidag, B.; Dalkan, C.; Yetkin, O.; Bahçeciler, N.N. Evaluation of Dose Dependent Maternal Exposure to Bisphenol A on Thyroid Functions in Newborns. J. Clin. Med. 2018, 7, 119.

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