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J. Clin. Med. 2015, 4(5), 1025-1035;

Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, Turin 10126, Italy
Division of Oncological Endocrinology, Department of Medical Sciences, University of Turin, Corso Bramante 88, Turin 10126, Italy
Author to whom correspondence should be addressed.
Academic Editors: Günter Stalla and Anna Kopczak
Received: 13 March 2015 / Revised: 25 April 2015 / Accepted: 4 May 2015 / Published: 19 May 2015
(This article belongs to the Special Issue Neuroendocrine Disturbances after Brain Damage)
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Background: Traumatic brain injury (TBI) is a leading cause of secondary hypopituitarism in children and adults, and is responsible for impaired quality of life, disabilities and compromised development. Alterations of pituitary function can occur at any time after the traumatic event, presenting in various ways and evolving during time, so they require appropriate screening for early detection and treatment. Although the exact pathophysiology is unknown, several mechanisms have been hypothesized, including hypothalamic-pituitary autoimmunity (HP-A). The aim of this study was to systematically review literature on the association between HP-A and TBI-induced hypopituitarism. Major pitfalls related to the HP-A investigation were also discussed. Methods: The PubMed database was searched with a string developed for this purpose, without temporal or language limits, for original articles assessing the association of HP-A and TBI-induced hypopituitarism. Results: Three articles from the same group met the inclusion criteria. Anti-pituitary and anti-hypothalamic antibodies were detected using indirect immunofluorescence in a significant number of patients with acute and chronic TBI. Elevated antibody titer was associated with an increased risk of persistent hypopituitarism, especially somatotroph and gonadotroph deficiency, while no correlations were found with clinical parameters. Conclusion: HPA seems to contribute to TBI-induced pituitary damage, although major methodological issues need to be overcome and larger studies are warranted to confirm these preliminary data. View Full-Text
Keywords: hypothalamic-pituitary autoimmunity; antipituitary antibodies; antihypothalamic antibodies; brain trauma injury hypothalamic-pituitary autoimmunity; antipituitary antibodies; antihypothalamic antibodies; brain trauma injury
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guaraldi, F.; Grottoli, S.; Arvat, E.; Ghigo, E. Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury. J. Clin. Med. 2015, 4, 1025-1035.

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