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Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use?

1
NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, 37 Queen Square, London WC1N 3BH, UK
2
UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
3
University College Hospital NHS Foundation Trust, London NW1 2PG, UK
4
Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Clin. Med. 2014, 3(2), 663-678; https://doi.org/10.3390/jcm3020663
Received: 19 February 2014 / Revised: 28 March 2014 / Accepted: 1 April 2014 / Published: 20 June 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 2)
The advantage of microarray (array) over conventional karyotype for the diagnosis of fetal pathogenic chromosomal anomalies has prompted the use of microarrays in prenatal diagnostics. In this review we compare the performance of different array platforms (BAC, oligonucleotide CGH, SNP) and designs (targeted, whole genome, whole genome, and targeted, custom) and discuss their advantages and disadvantages in relation to prenatal testing. We also discuss the factors to consider when implementing a microarray testing service for the diagnosis of fetal chromosomal aberrations. View Full-Text
Keywords: prenatal microarray; implementation; BAC; SNP prenatal microarray; implementation; BAC; SNP
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MDPI and ACS Style

Karampetsou, E.; Morrogh, D.; Chitty, L. Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which Platform Should We Use? J. Clin. Med. 2014, 3, 663-678.

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