Next Article in Journal
Distinct Hypoxemic Profiles of Obstructive Sleep Apnea in Southern Italy: The Living with OSA and CPAP Study
Previous Article in Journal
Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Multivessel Coronary Artery Disease
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 15
Issue 1
10.3390/jcm15010205
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Acute Respiratory Distress Syndrome in Patients with Intracerebral Hemorrhage

by
Thomas Christianson
1,
Terry Nowell
1,
Jay B. Lusk
2,3,
Anna C. Covington
4,
Wenjing Qi
5,
Jordan Komisarow
6,
Nazish Hashimi
7,
Shreyansh Shah
8,
Vijay Krishnamoorthy
7,
Yisi Ng
9 and
Michael L. James
7,8,*
1
Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, TN 37920, USA
2
School of Medicine, Duke University, Durham, NC 27710, USA
3
Fuqua School of Business, Duke University, Durham, NC 27708, USA
4
Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
5
Department of Biostatistics, Duke University, Durham, NC 27710, USA
6
Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710, USA
7
Department of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA
8
Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA
9
Duke-NUS Medical School, Singapore 169857, Singapore
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2026, 15(1), 205; https://doi.org/10.3390/jcm15010205 (registering DOI)
Submission received: 7 November 2025 / Revised: 15 December 2025 / Accepted: 17 December 2025 / Published: 26 December 2025
(This article belongs to the Topic Acute Respiratory Distress Syndrome (ARDS): Personalized Therapies and Beyond, 2nd Edition)
Versions Notes

Abstract

Introduction: Patients with an intracerebral hemorrhage (ICH) have been shown to have a high incidence of acute respiratory distress syndrome (ARDS). We aimed to determine the incidence of ARDS following ICH in the era of lung-protective ventilation. We also examined risk factors associated with ARDS following ICH. Materials and Methods: A retrospective cohort study of adults admitted to a single health system's intensive care units with acute, spontaneous ICH from 1 March 2015 to 28 February 2018, using univariate and multivariable logistic regression models to evaluate the associations of patient characteristics with the diagnosis of ARDS. Results: In total, 269 patients were included, with 155 patients requiring invasive mechanical ventilation. The overall incidence of ARDS was 6.7% (18/269), and the incidence in intubated patients was 10% (16/155), as the median time of ventilation with >8 cc/mL of ideal body weight was low. For the entire ICH population, severity of hypoxemia on initial arterial blood gas (ABG; Odds Ratio [OR] per 10 mmHg 0.855 [95% Confidence Interval [CI] 0.74–0.987]) and total minutes of mechanical ventilation (OR per 60 min 1.018 [95% CI 1.007–1.029]) were both associated with the diagnosis of ARDS. In intubated patients, ventilation, younger age (OR per 10 years 0.655 [95% CI 0.431–0.997]), and total minutes of mechanical ventilation (OR per 60 min 1.028 [95% CI 1.006–1.049] increased the odds of developing ARDS. Conclusions: ARDS was found to be significantly lower in the present cohort of ICH patients when compared to prior studies, with younger age and hypoxemia associated with an increasing risk.
Keywords: cerebral hemorrhage; respiratory distress syndrome; stroke; critical care; respiration cerebral hemorrhage; respiratory distress syndrome; stroke; critical care; respiration

Share and Cite

MDPI and ACS Style

Christianson, T.; Nowell, T.; Lusk, J.B.; Covington, A.C.; Qi, W.; Komisarow, J.; Hashimi, N.; Shah, S.; Krishnamoorthy, V.; Ng, Y.; et al. Acute Respiratory Distress Syndrome in Patients with Intracerebral Hemorrhage. J. Clin. Med. 2026, 15, 205. https://doi.org/10.3390/jcm15010205

AMA Style

Christianson T, Nowell T, Lusk JB, Covington AC, Qi W, Komisarow J, Hashimi N, Shah S, Krishnamoorthy V, Ng Y, et al. Acute Respiratory Distress Syndrome in Patients with Intracerebral Hemorrhage. Journal of Clinical Medicine. 2026; 15(1):205. https://doi.org/10.3390/jcm15010205

Chicago/Turabian Style

Christianson, Thomas, Terry Nowell, Jay B. Lusk, Anna C. Covington, Wenjing Qi, Jordan Komisarow, Nazish Hashimi, Shreyansh Shah, Vijay Krishnamoorthy, Yisi Ng, and et al. 2026. "Acute Respiratory Distress Syndrome in Patients with Intracerebral Hemorrhage" Journal of Clinical Medicine 15, no. 1: 205. https://doi.org/10.3390/jcm15010205

APA Style

Christianson, T., Nowell, T., Lusk, J. B., Covington, A. C., Qi, W., Komisarow, J., Hashimi, N., Shah, S., Krishnamoorthy, V., Ng, Y., & James, M. L. (2026). Acute Respiratory Distress Syndrome in Patients with Intracerebral Hemorrhage. Journal of Clinical Medicine, 15(1), 205. https://doi.org/10.3390/jcm15010205

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop