Dental Caries Status in Postmenopausal Women: Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Review Question
2.2. Eligibility Criteria
2.3. Search Strategy and Information Sources
2.4. Data Extraction
2.5. Data Synthesis and Analysis
2.6. Risk of Bias Assessment
- (A)
- Sample Selection Domain (maximum: 6 points):
- (1)
- Sample representativeness: random sampling (3 points), non-random sampling (2 points), selected groups (1 point), or no description (0 points).
- (2)
- Sample size: justified by calculations or entire population recruitment with ≤20% loss (1 point); otherwise, (0 points).
- (3)
- Menopausal status confirmation: cessation of menstruation (2 point); only by age (1 point); no criteria description (0 points).
- (B)
- Outcome Domain (maximum: 3 points):
- (1)
- Outcome assessment: DMFT index registered with inter- and intra-examiner reliability reported (2 points), partial reliability (1 point), or none (0 points).
- (2)
- Number of observers: Two or more examiners (1 point); otherwise (0 points).
2.7. Grading of Recommendations Assessment, Development, and Evaluation
3. Results
3.1. Characteristics of the Included Studies
3.2. Meta-Analysis of the Prevalence of Caries Assessed Using the DMFT Index
3.3. Risk of Bias Assessment
3.4. Publication Bias
3.5. GRADE Evaluation: Level of Certainty
4. Discussion
4.1. Risk of Bias of Included Studies
4.2. The Heterogeneity of the Included Studies
4.3. Menopause as a Risk Factor for Caries and Other Oral Diseases
4.4. Limitations and Strengths
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
DMFT | Decayed, Missing, and Filled Teeth |
MD | Mean Difference |
MESH | Medical Subject Headings |
CI | Confidence Interval |
GRADE | Grading of Recommendations Assessment, Development, and Evaluation |
HRT | Hormone Replacement Therapy |
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Reasons | Excluded Studies |
---|---|
Quantitative data not reported | Baum et al., 1981 [22] Mishra et al., 2021 [7] |
Absence of control group | Yalcin et al., 2006 [23] |
Author | Reference | Study Design | Subjects | Menopause–Caries Association |
---|---|---|---|---|
Lee et al., 2022 | [12] | Cross-sectional | Control—5131 Menopause—4396 | Yes p < 0.05 |
Foglio-Bonda et al., 2019 | [11] | Cross-sectional | Control—60 Menopause—60 | No p > 0.05 |
Rukmini et al., 2018 | [24] | Cross-sectional | Control—40 Menopause—60 | Yes p < 0.05 |
Parakh et al., 2018 | [25] | Cross-sectional | Control—40 Menopause—40 | Yes p < 0.05 |
Bhat et al., 2010 | [26] | Cross-sectional | Control—20 Menopause—20 | Yes p < 0.05 |
Dural et al., 2006 | [27] | Cross-sectional | Control—20 Menopause—18 | Yes p < 0.05 |
Yalcin et al., 2005 | [28] | Cross-sectional | Control—14 Menopause—14 | Yes p < 0.05 |
Authors | Sample Size | Control Women | Postmenopausal Women | MD (95% C.I.) | p | ||
---|---|---|---|---|---|---|---|
DMFT Index | Subjects | DMFT Index | Subjects | ||||
Lee et al., 2022 [12] | 9527 | 6.62 ± 5.19 | 5131 | 8.83 ± 8.22 | 4396 | 2.21 (1.82–2.6) | <0.05 |
Foglio-Bonda et al., 2019 [11] | 120 | 12.23 ± 6.36 | 60 | 11.93 ± 7.14 | 60 | −0.3 (−2.72–2.12) | >0.05 |
Rukmini et al., 2018 [24] | 80 | 1.38 ± 1.56 | 40 | 5.15 ± 2.94 | 40 | 3.77 (2.74–4.8) | <0.05 |
Parakh et al., 2016 [25] | 80 | 2.45 ± 0.81 | 40 | 5.10 ± 2.02 | 40 | 2.65 (1.98–3.32) | <0.05 |
Bhat et al., 2010 [26] | 40 | 2.30 ± 2.07 | 20 | 8.20 ± 4.58 | 20 | 5.9 (3.7–8.1) | <0.05 |
Dural et al., 2006 [27] | 38 | 5.7 ± 4.72 | 20 | 13.2 ± 6.02 | 18 | 7.5 (4.03–10.97) | <0.05 |
Yalcin et al., 2005 [28] | 28 | 8.21 ± 3.75 | 14 | 10.86 ± 3.11 | 14 | 2.65 (0.1–5.2) | <0.05 |
Studies | Sample Selection | Outcome | Risk of Bias | |||
---|---|---|---|---|---|---|
Representativeness | Sample Size | Menopausal Status | Outcome Assessment | No. of Observers | ||
Lee et al., 2022 [12] | *** | 0 | ** | * | 0 | Moderate (6) |
Foglio-Bonda et al., 2019 [11] | * | 0 | 0 | * | 0 | High (2) |
Rukmini et al., 2018 [24] | * | * | ** | * | 0 | Moderate (5) |
Parakh et al., 2016 [25] | * | 0 | ** | * | 0 | Moderate (4) |
Bhat et al., 2010 [26] | * | 0 | ** | * | 0 | Moderate (4) |
Dural et al., 2006 [27] | * | 0 | ** | * | 0 | Moderate (4) |
Yalcin et al., 2005 [28] | * | 0 | ** | * | 0 | Moderate (4) |
Overall | 9 | 1 | 12 | 7 | 0 | Moderate (29) |
No. of Studies | Study Design | Risk of Bias | Inconsistency | Indirectness | Imprecision | Other Considerations | Certainty |
---|---|---|---|---|---|---|---|
Postmenopausal women—dental caries status | |||||||
7 | Observational studies | Not serious a | Serious b | Serious | Serious c | MD = 3.13 (2.12–4.15) p < 0.00001 | ⊕○○○ Very low |
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Areal-Quecuty, V.; Segura-Egea, J.J.; Simón-Soro, A.; León-López, M.; Cantiga-Silva, C.; Martín-González, J.; Sánchez-Domínguez, B.; Cabanillas-Balsera, D. Dental Caries Status in Postmenopausal Women: Systematic Review and Meta-Analysis. J. Clin. Med. 2025, 14, 1837. https://doi.org/10.3390/jcm14061837
Areal-Quecuty V, Segura-Egea JJ, Simón-Soro A, León-López M, Cantiga-Silva C, Martín-González J, Sánchez-Domínguez B, Cabanillas-Balsera D. Dental Caries Status in Postmenopausal Women: Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2025; 14(6):1837. https://doi.org/10.3390/jcm14061837
Chicago/Turabian StyleAreal-Quecuty, Victoria, Juan J. Segura-Egea, Aurea Simón-Soro, María León-López, Cristiane Cantiga-Silva, Jenifer Martín-González, Benito Sánchez-Domínguez, and Daniel Cabanillas-Balsera. 2025. "Dental Caries Status in Postmenopausal Women: Systematic Review and Meta-Analysis" Journal of Clinical Medicine 14, no. 6: 1837. https://doi.org/10.3390/jcm14061837
APA StyleAreal-Quecuty, V., Segura-Egea, J. J., Simón-Soro, A., León-López, M., Cantiga-Silva, C., Martín-González, J., Sánchez-Domínguez, B., & Cabanillas-Balsera, D. (2025). Dental Caries Status in Postmenopausal Women: Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 14(6), 1837. https://doi.org/10.3390/jcm14061837