The Impact of Obesity on the Left Atrium and Arrhythmia Recurrence in Patients with Atrial Fibrillation Undergoing Ablation
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Patient Selection
2.2. Echocardiographic Assessment
2.3. Left Atrial Pressure Measurements
2.4. Ethical Statement
2.5. Statistical Methods
3. Results
3.1. Study Population
3.2. Data from the Assessment of LA, LV, and RV Sizes
3.3. Data from the Assessment of LA Function
3.4. Data from the Invasive and Noninvasive Assessment of LA Pressure
3.5. Subgroup Analysis
3.6. Analysis of Co-Occurrence of Independent Variables
3.7. AF Recurrence Rate in Study Population
4. Discussion
5. Study Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Group (n = 672) | |||
---|---|---|---|
Obese BMI ≥ 30 kg/m2 n = 308 (45.8%) | Non-Obese BMI < 30 kg/m2 n = 364 | p | |
BMI, median (IQR) | 33.2 (31.3–36) | 26.8 (24.7–28) | |
Demographic data | |||
Age, years, median (IQR) | 65 (57.5–70.5) | 67 (58.5–73) | 0.08 |
Female gender, n (%) | 119 (38.6) | 143 (39.3) | 0.86 |
HR (/min) | 70 (62–86) | 70 (62–87) | 0.78 |
AF during echocardiography | 104 (33.8) | 151 (41.5) | 0.25 |
Time from first AF diagnosis, years, median (IQR) | 3 (1–5) | 3 (1–6) | 0.91 |
Laboratory data | |||
Hemoglobin, g/dL | 14.7 (13.6–15.6) | 14.2 (13.3–15.2) | 0.002 |
WBC, tys/uL | 7.2 (6–8.7) | 6.8 (5.7–8.1) | 0.001 |
Creatinine, mg/dL | 1 (0.9–1.2) | 1 (0.8–1.1) | 0.03 |
eGFR, mL/min/m3 | 90 (59.5–90) | 90 (61–90) | 0.55 |
Clinical data, n(%) | |||
Hypertension | 268 (87) | 241 (66.2) | <0.0001 |
Diabetes mellitus | 80 (26) | 65 (17.9) | 0.01 |
Stroke | 16 (5.2) | 21 (5.8) | 0.87 |
Coronary artery disease | 85 (27.6) | 86 (23.6) | 0.28 |
Smoking | 80 (26) | 88 (24.2) | 0.61 |
HF | 117 (38) | 93 (25.5) | 0.0008 |
HFrEF | 32 (27.4) | 31 (33.3) | 0.49 |
HFmrEF | 33 (28.2) | 27 (29) | 0.17 |
HFpEF | 51 (43.6) | 38 (40.9) | 0.03 |
Whole Group (n = 672) | |||
---|---|---|---|
Obese BMI ≥ 30 kg/m2 n = 308 (45.8%) | Non-Obese BMI < 30 kg/m2 n = 364 | p | |
LVDd, mm | 51 (48–55.5) | 49 (46–53) | <0.0001 |
LVSd, mm | 35 (32–40) | 33 (30–37) | <0.0001 |
RVDd, mm | 32 (30–33.6) | 30 (28–32) | <0.0001 |
LVMI, g/m2 | 126 (104.5–152.3) | 111.3 (96.3–133.7) | <0.0001 |
E, cm/s | 74.5 (62.5–88) | 70 (57.5–82) | 0.002 |
e’ medial, cm/s | 7 (6–8) | 7 (6–9) | 0.05 |
e’ lateral, cm/s | 9 (7–11) | 9 (8–12) | 0.09 |
e’ average, cm/s | 8.5 (6.5–9.5) | 8.5 (7–10) | 0.09 |
E/e′ average | 8.94 (7.3–11.4) | 8.3 (6.4–10.5) | <0.001 |
LV EF, % | 60 (50–63) | 60 (53–65) | 0.01 |
LAd, mm | 46.4 (43.4–50.5) | 43.7 (40.7–46.9) | 0.0025 |
LA area, cm2 | 27.3 (24–31.5) | 25.2 (21.3–29.2) | <0.0001 |
RA area, cm2 | 19.6 (16.3–23.4) | 18 (15–21.1) | <0.0001 |
LAV, mL | 89 (75–110) | 79.3 (63.2–101) | <0.0001 |
LAVI [BSA], mL/m2 | 41.9 (35.2–51.5) | 41.7 (33.5–51.6) | 0.37 |
LAVI [h2], mL/m2 | 30.2 (25–36.9) | 26.8 (21.2–33.4) | <0.0001 |
LAEF, % | 37 (25–50) | 38 (24–50) | 0.81 |
LAAV, cm/s | 42 (30–60) | 45.5 (29.5–71) | 0.09 |
TRV, m/s | 2.4 (2.2–2.7) | 2.4 (2.1–2.6) | 0.07 |
SEC, n (%) | 39 (12.7) | 36 (9.9) | 0.29 |
Speckle tracking echocardiography data—left atrial and left ventricular function parameters | |||
LASr, %, median (IQR) | 14 (9–23) | 16 (10–24) | 0.2 |
LV GLS, %, median (IQR) | 17.3 (13.8–20.2) | 17.8 (14.1–20.5) | 0.2 |
LASI (E/e′/LASr), median (IQR) | 0.63 (0.34–1.09) | 0.51 (0.29–0.96) | 0.004 |
Electrophysiological data, median (IQR) | |||
LAP max | 23 (17–28) | 19 (15–25) | <0.0001 |
LAP med | 15 (12–19) | 13 (10–17) | <0.0001 |
LAP min | 10 (7–13) | 9 (6–11) | <0.0001 |
Variables | LA Area (cm2) | LAV (mL) | LAVI/H2 (mL/m2) | LASI | E Wave (cm/s) | E/e′ Avg Ratio | LAP Mean |
---|---|---|---|---|---|---|---|
BMI | |||||||
p | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
η2 | 0.07 | 0.08 | 0.09 | 0.06 | 0.05 | 0.06 | 0.05 |
Sex | |||||||
p | <0.001 | <0.001 | 0.33 | 0.008 | <0.001 | <0.001 | 0.23 |
η2 | 0.07 | 0.08 | 0.001 | 0.01 | 0.03 | 0.07 | 0.002 |
HT | |||||||
p | <0.001 | <0.001 | <0.001 | 0.004 | 0.009 | <0.001 | <0.001 |
η2 | 0.02 | 0.02 | 0.03 | 0.01 | 0.01 | 0.02 | 0.02 |
DM | |||||||
p | 0.009 | 0.005 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
η2 | 0.01 | 0.01 | 0.02 | 0.04 | 0.02 | 0.06 | 0.04 |
CKD | |||||||
p | 0.28 | 0.22 | 0.003 | 0.002 | 0.06 | 0.001 | 0.66 |
η2 | 0.002 | 0.002 | 0.01 | 0.02 | 0.005 | 0.02 | 0 |
CAD | |||||||
p | 0.001 | 0.001 | <0.001 | <0.001 | 0.17 | <0.001 | 0.33 |
η2 | 0.02 | 0.02 | 0.02 | 0.04 | 0.003 | 0.04 | 0.001 |
HF | |||||||
p | <0.001 | <0.001 | <0.001 | <0.001 | 0.006 | <0.001 | <0.001 |
η2 | 0.13 | 0.14 | 0.12 | 0.16 | 0.01 | 0.07 | 0.04 |
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Uziębło-Życzkowska, B.; Kiliszek, M.; Krzyżanowski, K.; Krzesiński, P. The Impact of Obesity on the Left Atrium and Arrhythmia Recurrence in Patients with Atrial Fibrillation Undergoing Ablation. J. Clin. Med. 2025, 14, 7043. https://doi.org/10.3390/jcm14197043
Uziębło-Życzkowska B, Kiliszek M, Krzyżanowski K, Krzesiński P. The Impact of Obesity on the Left Atrium and Arrhythmia Recurrence in Patients with Atrial Fibrillation Undergoing Ablation. Journal of Clinical Medicine. 2025; 14(19):7043. https://doi.org/10.3390/jcm14197043
Chicago/Turabian StyleUziębło-Życzkowska, Beata, Marek Kiliszek, Krystian Krzyżanowski, and Paweł Krzesiński. 2025. "The Impact of Obesity on the Left Atrium and Arrhythmia Recurrence in Patients with Atrial Fibrillation Undergoing Ablation" Journal of Clinical Medicine 14, no. 19: 7043. https://doi.org/10.3390/jcm14197043
APA StyleUziębło-Życzkowska, B., Kiliszek, M., Krzyżanowski, K., & Krzesiński, P. (2025). The Impact of Obesity on the Left Atrium and Arrhythmia Recurrence in Patients with Atrial Fibrillation Undergoing Ablation. Journal of Clinical Medicine, 14(19), 7043. https://doi.org/10.3390/jcm14197043