Correlation of Airway POCUS Measures with Screening and Severity Evaluation Tools in Obstructive Sleep Apnea: An Exploratory Study
Abstract
1. Introduction
2. Methods
2.1. Study Design and Setting
2.2. Study Population
2.3. Recruitment and Scanning Technique
2.4. Statistical Analyses
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
AHI | Apnea–Hypopnea Index |
BMI | Body Mass Index |
CI | Confidence Interval |
CRF | Case Report Form |
CSAT-S | Cross-Sectional Area of the Tongue in the Sagittal Plane |
DLA | Distance Between Lingual Arteries |
ENT | Ear, Nose, and Throat |
FDA | Food and Drug Administration |
GMT | Geniohyoid Muscle Thickness |
IQR | Interquartile Range |
IRB | Institutional Review Board |
LPWT | Lateral Parapharyngeal Wall Thickness |
R LPWT | Right Lateral Parapharyngeal Wall Thickness |
L LPWT | Left Lateral Parapharyngeal Wall Thickness |
MRI | Magnetic Resonance Imaging |
NCT | National Clinical Trial |
OSA | Obstructive Sleep Apnea |
POCUS | Point-of-Care Ultrasound |
PSG | Polysomnography |
RPD | Retro-palatal Diameter |
RGD | Retro-glossal Distance |
SBQ | STOP-BANG Questionnaire |
SD | Standard Deviation |
STOP-BANG | A screening tool for Obstructive Sleep Apnea (OSA) with eight components: “S” stands for significant Snoring; “T” for excessive Tiredness; “O” for Observed breathing cessations during sleep; “P” for high blood Pressure; “B” for BMI over 35 kg/m2; “A” for Age over 50 years; “N” for Neck circumference greater than 40 cm; and “G” for male Gender. Each element helps to assess OSA risk factors. |
SHD | Skin–Hyoid Distance |
TBT | Tongue Base Thickness |
TBT-S | Tongue Base Thickness—Sagittal |
TBT-C | Tongue Base Thickness—Coronal |
T-CSA | Tongue Cross-Sectional Area |
TDP | Transverse Diameter of Pharynx |
UAL | Upper Airway Length |
References
- Memtsoudis, S.G.; Besculides, M.C.; Mazumdar, M. A rude awakening—The perioperative sleep apnea epidemic. N. Engl. J. Med. 2013, 368, 2352–2353. [Google Scholar] [PubMed]
- Pichler, L.; Weinstein, S.M.; Cozowicz, C.; Poeran, J.; Liu, J.; Poultsides, L.A.; Saleh, J.N.; Memtsoudis, S.G. Perioperative impact of sleep apnea in a high-volume specialty practice with a strong focus on regional anesthesia: A database analysis. Reg. Anesth. Pain Med. 2019, 44, 303–308. [Google Scholar] [CrossRef] [PubMed]
- Stundner, O.; Zubizarreta, N.; Mazumdar, M.; Memtsoudis, S.G.; Wilson, L.A.; Ladenhauf, H.N.; Poeran, J. Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy: A Population-Based Observational Study. Anesth. Analg. 2021, 133, 755–764. [Google Scholar] [CrossRef]
- Franklin, K.A.; Lindberg, E. Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea. J. Thorac. Dis. 2015, 7, 1311–1322. [Google Scholar] [CrossRef]
- Liu, Y.; Wheaton, A.G.; Greenlund, K.K.; Croft, J.B. Sleep Disorder Symptoms Among Adults in 8 States and the District of Columbia, 2017. Prev. Chronic Dis. 2021, 18, E105. [Google Scholar] [CrossRef] [PubMed]
- Finkel, K.J.; Searleman, A.C.; Tymkew, H.; Tanaka, C.Y.; Saager, L.; Safer-Zadeh, E.; Bottros, M.; Selvidge, J.A.; Jacobsohn, E.; Pulley, D.; et al. Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center. Sleep Med. 2009, 10, 753–758. [Google Scholar] [CrossRef]
- Singh, M.; Liao, P.; Kobah, S.; Wijeysundera, D.; Shapiro, C.; Chung, F. Proportion of surgical patients with undiagnosed obstructive sleep apnoea. Br. J. Anaesth. 2013, 110, 629–636. [Google Scholar]
- Kim, J.-Y.; Ko, I.; Kim, D.-K. Association of Obstructive Sleep Apnea With the Risk of Affective Disorders. JAMA Otolaryngol. Head Neck Surg. 2019, 145, 1020–1026. [Google Scholar] [CrossRef]
- Tregear, S.; Reston, J.; Schoelles, K.; Phillips, B. Obstructive sleep apnea and risk of motor vehicle crash: Systematic review and meta-analysis. J. Clin. Sleep Med. 2009, 5, 573–581. [Google Scholar]
- Yeghiazarians, Y.; Jneid, H.; Tietjens, J.R.; Redline, S.; Brown, D.L.; El-Sherif, N.; Mehra, R.; Bozkurt, B.; Ndumele, C.E.; Somers, V.K. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2021, 144, e56–e67. [Google Scholar] [CrossRef]
- Mutter, T.C.; Chateau, D.; Moffatt, M.; Ramsey, C.; Roos, L.L.; Kryger, M. A matched cohort study of postoperative outcomes in obstructive sleep apnea: Could preoperative diagnosis and treatment prevent complications? Anesthesiology 2014, 121, 707–718. [Google Scholar] [PubMed]
- Memtsoudis, S.G.; Stundner, O.; Rasul, R.; Chiu, Y.L.; Sun, X.; Ramachandran, S.K.; Kaw, R.; Fleischut, P.; Mazumdar, M. The impact of sleep apnea on postoperative utilization of resources and adverse outcomes. Anesth. Analg. 2014, 118, 407. [Google Scholar] [PubMed]
- Chung, F.; Memtsoudis, S.G.; Ramachandran, S.K.; Nagappa, M.; Opperer, M.; Cozowicz, C.; Patrawala, S.; Lam, D.; Kumar, A.; Joshi, G.P.; et al. Society of anesthesia and sleep medicine guidelines on preoperative screening and assessment of adult patients with obstructive sleep apnea. Anesth. Analg. 2016, 123, 452. [Google Scholar]
- Chang, J.L.; Goldberg, A.N.; Alt, J.A.; Mohammed, A.; Ashbrook, L.; Auckley, D.; Ayappa, I.; Bakhtiar, H.; Barrera, J.E.; Bartley, B.L.; et al. International Consensus Statement on Obstructive Sleep Apnea. Int. Forum Allergy Rhinol. 2023, 13, 1061–1482. [Google Scholar] [CrossRef]
- Fouladpour, N.; Jesudoss, R.; Bolden, N.; Shaman, Z.; Auckley, D. Perioperative complications in obstructive sleep apnea patients undergoing surgery: A review of the legal literature. Anesth. Analg. 2016, 122, 145–151. [Google Scholar]
- Auckley, D.; Bolden, N. Preoperative screening and perioperative care of the patient with sleep-disordered breathing. Curr. Opin. Pulm. Med. 2012, 18, 588–595. [Google Scholar] [CrossRef]
- Subramani, Y.; Wong, J.; Nagappa, M.; Chung, F. The Benefits of Perioperative Screening for Sleep Apnea in Surgical Patients. Sleep Med. Clin. 2017, 12, 123–135. [Google Scholar] [CrossRef]
- Toraldo, D.M.; Passali, D.; Sanna, A.; De Nuccio, F.; Conte, L.; De Benedetto, M. Cost-effectiveness strategies in OSAS management: A short review. Acta Otorhinolaryngol. Ital. 2017, 37, 447–453. [Google Scholar] [CrossRef] [PubMed]
- Kalagara, H.; Manson, W.; Townsley, M.M. Point-of-Care Ultrasound (POCUS) Training for Anesthesiologists: Is it Time to Embrace and Attain Competency? J. Cardiothorac. Vasc. Anesth. 2022, 36, 30–32. [Google Scholar] [CrossRef]
- Lee, S.C.; Yang, E.C.; Navarro, J.C.; Minard, C.G.; Huang, X.; Deng, Y. An Introductory Point-of-Care Ultrasound Curriculum for an Anesthesiology Residency Program. MedEdPORTAL 2022, 18, 11291. [Google Scholar] [CrossRef]
- Burns, D.W.; Chan, V.W.S.; Trivedi, A.; Englesakis, M.; Munshey, F.; Singh, M. Ready to scan? A systematic review of point of care ultrasound (PoCUS) for screening of obstructive sleep apnea (OSA) in the pediatric population. J. Clin. Anesth. 2022, 83, 110973. [Google Scholar] [CrossRef] [PubMed]
- Kalkanis, A.; Testelmans, D.; Papadopoulos, D.; Van den Driessche, A.; Buyse, B. Insights into the Use of Point-of-Care Ultrasound for Diagnosing Obstructive Sleep Apnea. Diagnostics 2023, 13, 2262. [Google Scholar] [PubMed]
- Singh, M.; Tuteja, A.; Wong, D.T.; Goel, A.; Trivedi, A.; Tomlinson, G.; Chan, V. Point-of-care ultrasound for obstructive sleep apnea screening: Are we there yet? A systematic review and meta-analysis. Anesth. Analg. 2019, 129, 1673–1691. [Google Scholar] [PubMed]
- Wang, D.; Martins, R.T.; Rowsell, L.; Wong, K.K.; Yee, B.J.; Grunstein, R.R.; Eckert, D.J. Comparison of awake respiratory control versus sleep obstructive sleep apnea endotypes. J. Appl. Physiol. 2024, 137, 1524–1534. [Google Scholar] [CrossRef] [PubMed]
- Stauffer, J.L.; Zwillich, C.W.; Cadieux, R.J.; Bixler, E.O.; Kales, A.; Varano, L.A.; White, D.P. Pharyngeal size and resistance in obstructive sleep apnea. Am. Rev. Respir. Dis. 1987, 136, 623–627. [Google Scholar]
- Brown, I.G.; Bradley, T.D.; Phillipson, E.A.; Zamel, N.; Hoffstein, V. Pharyngeal compliance in snoring subjects with and without obstructive sleep apnea. Am. Rev. Respir. Dis. 1985, 132, 211–215. [Google Scholar]
- Bradley, T.D.; Brown, I.G.; Grossman, R.F.; Zamel, N.; Martinez, D.; Phillipson, E.A.; Hoffstein, V. Pharyngeal size in snorers, nonsnorers, and patients with obstructive sleep apnea. N. Engl. J. Med. 1986, 315, 1327–1331. [Google Scholar]
- RadiAnt DICOM Viewer, Version 2020.1, Medixant: Poznań, Poland, 2020. Available online: https://www.radiantviewer.com (accessed on 17 July 2024).
- Chen, J.W.; Chang, C.H.; Wang, S.J.; Chang, Y.T.; Huang, C.C. Submental ultrasound measurement of dynamic tongue base thickness in patients with obstructive sleep apnea. Ultrasound Med. Biol. 2014, 40, 2590–2598. [Google Scholar] [CrossRef]
- Lahav, Y.; Rosenzweig, E.; Heyman, Z.; Doljansky, J.; Green, A.; Dagan, Y. Tongue base ultrasound: A diagnostic tool for predicting obstructive sleep apnea. Ann. Otol. Rhinol. Laryngol. 2009, 118, 179–184. [Google Scholar] [CrossRef]
- Liu, K.H.; Chu, W.C.; To, K.W.; Ko, F.W.; Tong, M.W.; Chan, J.W.; Hui, D.S. Sonographic measurement of lateral parapharyngeal wall thickness in patients with obstructive sleep apnea. Sleep 2007, 30, 1503–1508. [Google Scholar] [CrossRef]
- Shu, C.C.; Lee, P.; Lin, J.W.; Huang, C.T.; Chang, Y.C.; Yu, C.J.; Wang, H.C. The use of sub-mental ultrasonography for identifying patients with severe obstructive sleep apnea. PLoS ONE. 2013, 8, e62848. [Google Scholar] [CrossRef] [PubMed]
- Wanderer, J.P.; Nathan, N. Hocus, PoCUS: OSA Diagnosis? Anesth. Analg. 2019, 129, 1444. [Google Scholar] [CrossRef] [PubMed]
Characteristic | Median (IQR) |
---|---|
Age | 63.00 (23.00) |
Height | 168.90 (16.3) |
Weight | 99.70 (21.0) |
BMI | 34.48 (8.64) |
STOP-BANG score | Number of patients (percentage) |
0 | 1 (0.8%) |
1 | 2 (1.6%) |
2 | 7 (5.6%) |
3 | 7 (5.6%) |
4 | 20 (16%) |
5 | 30 (24%) |
6 | 33 (26%) |
7 | 19 (15%) |
8 | 7 (5.6%) |
Characteristic | Median (IQR) |
---|---|
Tongue Base Thickness—Sagittal (TBT-S) (cm) | 6.80 (6.32, 7.49) |
TBT-S during Muller Maneuver (cm) | 6.78 (6.37, 7.43) |
Tongue Base Thickness—Coronal (TBT-C) (cm) | 6.67 (6.25, 7.31) |
Upper Airway Length (UAL) (cm) | 2.78 (2.20, 3.74) |
UAL during Muller Maneuver (cm) | 2.53 (2.12, 3.19) |
Left Lateral Pharyngeal Wall Thickness (cm) | 1.17 (0.95, 1.35) |
Right Lateral Pharyngeal Wall Thickness (cm) | 1.14 (0.93, 1.35) |
Tongue Cross Sectional Area (T-CSA) (cm2) | 24.8 (22.5, 27.1) |
Distance between Lingual Arteries (DLA) (cm) | 2.96 (2.63, 3.30) |
Retro-Palatal Diameter (RPD) (cm) | 4.26 (3.63, 4.69) |
Retro-Glossal Diameter (RGD) (cm) | 3.48 (2.71, 3.93) |
Transverse Diameter of the Pharynx (cm) | 3.86 (3.25, 4.38) |
Geniohyoid Muscle Thickness (GMT) (cm) | 0.83 (0.72, 1.00) |
Skin-Hyoid Distance (SHD) (cm) | 1.35 (1.07, 1.69) |
Neck circumference (cm) | 46 (42, 50) |
AHI | 16 (8, 31) |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Ravindranath, S.; Ranganath, Y.S.; Lemke, E.; Behrens, M.B.; Marian, A.A.; Kalagara, H.; Sadek, N.; Seering, M.S.; Wendt, L.; Ten Eyck, P.; et al. Correlation of Airway POCUS Measures with Screening and Severity Evaluation Tools in Obstructive Sleep Apnea: An Exploratory Study. J. Clin. Med. 2025, 14, 4858. https://doi.org/10.3390/jcm14144858
Ravindranath S, Ranganath YS, Lemke E, Behrens MB, Marian AA, Kalagara H, Sadek N, Seering MS, Wendt L, Ten Eyck P, et al. Correlation of Airway POCUS Measures with Screening and Severity Evaluation Tools in Obstructive Sleep Apnea: An Exploratory Study. Journal of Clinical Medicine. 2025; 14(14):4858. https://doi.org/10.3390/jcm14144858
Chicago/Turabian StyleRavindranath, Sapna, Yatish S. Ranganath, Ethan Lemke, Matthew B Behrens, Anil A. Marian, Hari Kalagara, Nada Sadek, Melinda S. Seering, Linder Wendt, Patrick Ten Eyck, and et al. 2025. "Correlation of Airway POCUS Measures with Screening and Severity Evaluation Tools in Obstructive Sleep Apnea: An Exploratory Study" Journal of Clinical Medicine 14, no. 14: 4858. https://doi.org/10.3390/jcm14144858
APA StyleRavindranath, S., Ranganath, Y. S., Lemke, E., Behrens, M. B., Marian, A. A., Kalagara, H., Sadek, N., Seering, M. S., Wendt, L., Ten Eyck, P., & Sondekoppam, R. V. (2025). Correlation of Airway POCUS Measures with Screening and Severity Evaluation Tools in Obstructive Sleep Apnea: An Exploratory Study. Journal of Clinical Medicine, 14(14), 4858. https://doi.org/10.3390/jcm14144858