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Volume 14
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Predictive Value of Left Ventricular Systolic Dysfunction or Wall Motion Abnormalities for Non-Ischemic Myocardial Injury: A Multicenter Cardiovascular Resonance Study

by
Justyna M. Sokolska
1,2,
Justyna Rajewska-Tabor
3,
Marek Koziński
4,5,
Dorota Kulawiak-Gałąska
6,
Anna Jankowska
7,
Małgorzata Pyda
3,
Karol Miszalski-Jamka
8 and
Maciej Haberka
9,10,*
1
Department of Cardiovascular Imaging, Faculty of Medicine, Institute of Heart Diseases, Wroclaw Medical University, 50-556 Wrocław, Poland
2
Institute of Heart Diseases, Wroclaw University Hospital, 50-556 Wrocław, Poland
3
1st Department of Cardiology, Poznan University of Medical Sciences, 61-848 Poznań, Poland
4
Department of Cardiology, Kociewie Health Center, 83-200 Starogard Gdański, Poland
5
1st Department of Cardiology, Medical University of Gdansk, 80-214 Gdańsk, Poland
6
2nd Department of Radiology, Medical University of Gdańsk, 80-214 Gdańsk, Poland
7
Department of Cardiology, Stefan Cardinal Wyszynski Regional Specialist Hospital, 20-718 Lublin, Poland
8
Diagnostic Imaging Department, Silesian Center for Heart Diseases, 41-800 Zabrze, Poland
9
Department of Cardiology, School of Health Sciences, Medical University of Silesia, 40-635 Katowice, Poland
10
Department of Cardiovascular Imaging, Upper Silesian Medical Center of the Medical University of Silesia, 40-635 Katowice, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2025, 14(11), 3691; https://doi.org/10.3390/jcm14113691 (registering DOI)
Submission received: 11 April 2025 / Revised: 14 May 2025 / Accepted: 22 May 2025 / Published: 24 May 2025
(This article belongs to the Special Issue Cardiac Magnetic Resonance Imaging: Current Techniques and Future Directions)
Versions Notes

Abstract

Background: Left ventricle (LV) systolic dysfunction, defined as a global (LVejection fraction, LVEF < 50%) and/or regional wall motion abnormalities (RWMA), are the major parameters assessed in patients with cardiovascular diseases. The study evaluated the predictive value of LV systolic dysfunction for non-ischemic myocardial injury (presence of myocardial fibrosis/scar) in patients with suspected myocarditis. Methods: This was a multicenter, observational, retrospective study (2018–2021) of stable outpatients with clinically suspected myocarditis referred for a contrast-enhanced CMR. Patients with a history of any other significant cardiovascular disorders were excluded from the study. In each patient, the LV systolic function (LVEF, RWMA) and the presence and severity of late gadolinium enhancement (LGE) were assessed by CMR. Results: A total of 773 consecutive patients were enrolled in the study. The average LVEF was 58 ± 10%, and systolic dysfunction was observed in 95 cases (12%). Subsequently, 456 patients (59%) with confirmed non-ischemic LGE in at least one segment were included in the study group. The average LVEF was 57 ± 11%, with LV systolic dysfunction observed in 126 (28%) individuals with RWMA and 84 (18%) with LVEF < 50%. The median number of LV segments with LGE was 3 (2–5), and the total amount of LGE was 6% (3–10) of the LV mass. The wall motion score index (WMSI) > 1 and LVEF < 56% were the best predictors of non-ischemic injury based on LGE (area under the curve [AUC] 0.62; sensitivity 31%; specificity 94%; p < 0.001 and AUC 0.59; sensitivity 42%; specificity 75%, p < 0.001, respectively). Conclusions: In stable patients with suspected myocarditis, any RWMA and LVEF < 56% had a predictive value for a non-ischemic myocardial injury as assessed by CMR.
Keywords: CMR; LGE; myocardial injury; systolic dysfunction; wall motion abnormalities CMR; LGE; myocardial injury; systolic dysfunction; wall motion abnormalities

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MDPI and ACS Style

Sokolska, J.M.; Rajewska-Tabor, J.; Koziński, M.; Kulawiak-Gałąska, D.; Jankowska, A.; Pyda, M.; Miszalski-Jamka, K.; Haberka, M. Predictive Value of Left Ventricular Systolic Dysfunction or Wall Motion Abnormalities for Non-Ischemic Myocardial Injury: A Multicenter Cardiovascular Resonance Study. J. Clin. Med. 2025, 14, 3691. https://doi.org/10.3390/jcm14113691

AMA Style

Sokolska JM, Rajewska-Tabor J, Koziński M, Kulawiak-Gałąska D, Jankowska A, Pyda M, Miszalski-Jamka K, Haberka M. Predictive Value of Left Ventricular Systolic Dysfunction or Wall Motion Abnormalities for Non-Ischemic Myocardial Injury: A Multicenter Cardiovascular Resonance Study. Journal of Clinical Medicine. 2025; 14(11):3691. https://doi.org/10.3390/jcm14113691

Chicago/Turabian Style

Sokolska, Justyna M., Justyna Rajewska-Tabor, Marek Koziński, Dorota Kulawiak-Gałąska, Anna Jankowska, Małgorzata Pyda, Karol Miszalski-Jamka, and Maciej Haberka. 2025. "Predictive Value of Left Ventricular Systolic Dysfunction or Wall Motion Abnormalities for Non-Ischemic Myocardial Injury: A Multicenter Cardiovascular Resonance Study" Journal of Clinical Medicine 14, no. 11: 3691. https://doi.org/10.3390/jcm14113691

APA Style

Sokolska, J. M., Rajewska-Tabor, J., Koziński, M., Kulawiak-Gałąska, D., Jankowska, A., Pyda, M., Miszalski-Jamka, K., & Haberka, M. (2025). Predictive Value of Left Ventricular Systolic Dysfunction or Wall Motion Abnormalities for Non-Ischemic Myocardial Injury: A Multicenter Cardiovascular Resonance Study. Journal of Clinical Medicine, 14(11), 3691. https://doi.org/10.3390/jcm14113691

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